The use of electronic teaching materials could increase students’ interest in learning. An electronic module was one of the teaching materials. This study aimed to see the feasibility of the electronic module material for thecirculatory system. We used the research and development method. This study’s method had steps that included potential and problems, data collection, product design, design validation, design revision, and product testing. Five validators validated product design. The data analysis used the CVR and CVI values for each criterion in the validation aspect which are course, graphic, contents, and language with a minimum value of 0.99. The study found two important findings. First, from the validator, the CVR values in all elements had a value of 1, and the CVI results each had a value of 1. Hence, the electronic module of the circulatory system material is declared valid and feasible to use. Second, the product trial obtained an overall average score of 88.4% and was very positive. It means that the electronic module could be an alternative teaching material used in the learning process at school or self-study for the student at home.

Background:The decoction of red dragon fruit peel contains chemical components with antioxidant activity of lowering blood LDL cholesterol levels. Objective: This research aimed to evaluate the antihypercholesterolemic power of red dragon fruit peel ethanolic extract. Materials and Methods: A total of 24 mice were divided into four treatment groups, each receiving distilled water at dose 0.39 ml/20 g body weight (A), red dragon fruit peel extract at dose 5.40 mg/20 g body weight (B) and 10.80 mg/20 g body weight (C), also simvastatin at dose 0.026 mg/20 g body weight (D). All experimental animals were given high fat intake in cow brain suspension for 60 days to increase LDL cholesterol levels in the blood. For 14 consecutive days, hypercholesterolemic mice were given test preparations. Mice were sacrificed on day 75 for blood and aortic samples. Results: The average blood LDL cholesterol levels in mice were 91.67 mg/dl, 63.23 mg/dl, 43.52 mg/dl, and 32.94 mg/dl (p<0.05%). Meanwhile, the average aortic score was 1.09, 0.79, 0.76, and 0.91 in the groups A, B, C and D, respectively. Conclusion: Red dragon fruit peel extract at a dose of 5.4 mg/20 g and 10.8 mg/20 g body weight reduces blood LDL cholesterol levels and the risk of atherosclerosis.