BACKGROUND: Adherence with health protocols during the Coronavirus disease (COVID-19) pandemic is very important to prevent transmission. However, it is obtained that adherence with health protocols is still not optimal. The hospital environment is an area that is at high risk of transmission. AIM: The purpose of this study is to analyze the relationship between health belief and adherence with the health protocol in the patient’s family. METHODS: Quantitative research is correlated with a cross-sectional approach. The sample is the family of patients at the hospital, which was taken with simple random sampling technique as many as 100 people. Research variables include perceived susceptibility, perceived severity, perceived benefits, perceived barrier, self-efficacy, and adherence with health protocols. Data collection was using questionnaire instruments. Data analysis was using Fisher test with a significance level of 95%. RESULTS AND DISCUSSION: Fisher’s test results obtained data that there is a relationship between health belief in the dimensions of perceived susceptibility (p = 0.007), perceived severity (p = 0.027), perceived benefits (p = 0.003), perceived barriers (p = 0.021), and self-efficacy (p = 0.002) with adherence with health protocols in an effort to prevent the transmission of COVID-19. The patient’s family will be willing to implement health protocols if they have a high health belief in efforts to prevent the transmission of COVID-19. This health belief includes the belief that COVID-19 disease is easily contagious and serious; adherence will provide benefits for health. CONCLUSION: Health beliefs are significantly related to adherence with health protocols in the prevention of COVID-19 transmission in the patient’s family.