Matrix metalloproteinases (MMPs) are responsible for remodeling and degrading extracellular matrix and basement membrane components. MMP-3 and -8 levels were assessed in this study during the early healing phase following a guided tissue regeneration (GTR) procedure. 32 patients, having 2 or 3 walled intrabony defects of PD > or =6 mm, were stratified into 2 groups on the basis of age, sex, smoking status and disease severity. All intrabony defects were treated using the resorbable Guidor membrane but only 1 group of patients was given a pre-operative dosage of antibiotic (3 g amoxycillin). GCF samples for the quantification of MMP-3 and -8 levels were obtained from the intrabony site where a membrane was placed (membrane site), from the non-adjacent site on the adjacent tooth which was involved in the surgical flap (surgical control site), and from a healthy site (healthy) on the contralateral side. The GCF samples taken at baseline, 1 week, 4 weeks and 3 months after surgery were analyzed using an enzyme linked immunoabsorbent essay (ELISA) for MMP-3 and using a time-resolved immunofluorescence assay (IFMA) for MMP-8. MMP-3 was detected in a very low % of sites at baseline while relatively high levels of MMP-8 were detected at all 3 types of sites at baseline. MMP-8 levels increased for all sites at week 1, and this was statistically significant for the membrane site, but at week 4, the levels decreased for both the membrane and the surgical sites. There was no statistically significant difference between the levels of MMP-3 and -8 in the antibiotic and non-antibiotic group. Collagen remodelling occurs during the early wound healing period following surgical and regenerative procedures. The levels of MMP-3 and -8 in GCF appear to reflect these processes. Interestingly, the presence of the membranes appeared to increase the levels of MMP-3 and -8 and may relate to the resorption of the resorbable membrane by host systems.

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AbstrakPasien perioperatif gastrointestinal berisiko tinggi mengalami malnutrisi. Malnutrisi dapat menyebabkan hasil yang tidak diharapkan pada asuhan keperawatan perioperatif. Penelitian ini bertujuan untuk mengidentifikasi hubungan status gizi pasien bedah gastrointestinal berdasarkan parameter antropometri (Indeks Massa Tubuh, Tebal Lipatan Kulit, dan Lingkar Lengan Atas) dan klinis (albumin dan tingkat hemoglobin) dengan penyembuhan luka dan lama rawat inap, serta mengidentifikasi asupan makanan pasien pra dan pasca operasi. Penelitian cross-sectional ini mengukur 38 pasien yang menjalani pembedahan gastrointestinal di sebuah rumah sakit umum daerah di Indonesia. IMT, TLK, LLA, albumin dan kadar hemoglobin diukur sebelum dan sesudah operasi. asupan makanan diukur dengan 24 jam makanan Recall. Sementara penyembuhan luka pasien diukur pada hari ke-3 dan ke-7 hari pasca pembedahan. Terjadi peningkatan prevalensi malnutrisi pada pasien sebesar 60% selama tinggal di rumah sakit. IMT dan kadar albumin secara bermakna berhubungan dengan penyembuhan luka (p <0,05). Rerata lama rawat inap pasien dengan IMT normal (13,8 ± 5,6 hari) lebih pendek dari pasien gizi kurang (27,8 ± 17,7 hari) dan pasien gizi lebih (22,4 ± 11,6 hari). Asupan pasien umumnya di bawah kebutuhan mereka. IMT, tingkat albumin, dan asupan makanan memiliki peran penting untuk penyembuhan luka dan lama rawat inap pasien pembedahan gastrointestinal di rumah sakit. Rumah sakit harus melakukan penilaian awal status gizi pasien (setidaknya IMT dan kadar albumin) untuk mengidentifikasi kebutuhan pasien, dan memberikan intervensi yang tepat sebelum dan setelah operasi.Kata kunci: Kadar albumin, lama rawat inap, penyembuhan luka, status gizi. Body Mass Index and Albumin Level related to Wound Healing AbstractPatients with gastrointestinal perioperative are at high risk of being malnutrition. Malnutrition could cause an adverse outcome of perioperative nursing care. This study aimed to identify the relationship of nutritional status of gastrointestinal surgical patients based on anthropometrical (Body Mass Index, Tricep Skin Fold, Mid Arm Circumference) and clinical laboratory (albumin and haemoglobin level) parameters to wound healing and length of stay (LOS), and identify food intake of patients pre and post surgery. This cross-sectional study included 38 patients who were undergoing gastrointestinal surgery at a regional hospital in Indonesia. BMI, TSF, MAC, albumin and hemoglobin level were measured pre and post surgery. Food intake was measured by 24 hours Food Recall. While patients wound healing was measured on the 3rd and 7thday of surgery. Malnutrition among patients increases 60% during the stay in the hospital. BMI and albumin level were significantly related to wound healing (p<0,05). The average LOS of patients with normal BMI (13.8 ± 5.6 days) was shorter than the underweight patient (27.8 ± 17.7 days) and overweight patients (22.4 ± 11.6 days). Intake of patients was generally under the need of their body. BMI status, albumin level, and food i...

AbstrakPasien perioperatif gastrointestinal berisiko tinggi mengalami malnutrisi. Malnutrisi dapat menyebabkan hasil yang tidak diharapkan pada asuhan keperawatan perioperatif. Penelitian ini bertujuan untuk mengidentifikasi hubungan status gizi pasien bedah gastrointestinal berdasarkan parameter antropometri (Indeks Massa Tubuh, Tebal Lipatan Kulit, dan Lingkar Lengan Atas) dan klinis (albumin dan tingkat hemoglobin) dengan penyembuhan luka dan lama rawat inap, serta mengidentifikasi asupan makanan pasien pra dan pasca operasi. Penelitian cross-sectional ini mengukur 38 pasien yang menjalani pembedahan gastrointestinal di sebuah rumah sakit umum daerah di Indonesia. IMT, TLK, LLA, albumin dan kadar hemoglobin diukur sebelum dan sesudah operasi. asupan makanan diukur dengan 24 jam makanan Recall. Sementara penyembuhan luka pasien diukur pada hari ke-3 dan ke-7 hari pasca pembedahan. Terjadi peningkatan prevalensi malnutrisi pada pasien sebesar 60% selama tinggal di rumah sakit. IMT dan kadar albumin secara bermakna berhubungan dengan penyembuhan luka (p <0,05). Rerata lama rawat inap pasien dengan IMT normal (13,8 ± 5,6 hari) lebih pendek dari pasien gizi kurang (27,8 ± 17,7 hari) dan pasien gizi lebih (22,4 ± 11,6 hari). Asupan pasien umumnya di bawah kebutuhan mereka. IMT, tingkat albumin, dan asupan makanan memiliki peran penting untuk penyembuhan luka dan lama rawat inap pasien pembedahan gastrointestinal di rumah sakit. Rumah sakit harus melakukan penilaian awal status gizi pasien (setidaknya IMT dan kadar albumin) untuk mengidentifikasi kebutuhan pasien, dan memberikan intervensi yang tepat sebelum dan setelah operasi.Kata kunci: Kadar albumin, lama rawat inap, penyembuhan luka, status gizi. Body Mass Index and Albumin Level related to Wound Healing AbstractPatients with gastrointestinal perioperative are at high risk of being malnutrition. Malnutrition could cause an adverse outcome of perioperative nursing care. This study aimed to identify the relationship of nutritional status of gastrointestinal surgical patients based on anthropometrical (Body Mass Index, Tricep Skin Fold, Mid Arm Circumference) and clinical laboratory (albumin and haemoglobin level) parameters to wound healing and length of stay (LOS), and identify food intake of patients pre and post surgery. This cross-sectional study included 38 patients who were undergoing gastrointestinal surgery at a regional hospital in Indonesia. BMI, TSF, MAC, albumin and hemoglobin level were measured pre and post surgery. Food intake was measured by 24 hours Food Recall. While patients wound healing was measured on the 3rd and 7thday of surgery. Malnutrition among patients increases 60% during the stay in the hospital. BMI and albumin level were significantly related to wound healing (p<0,05). The average LOS of patients with normal BMI (13.8 ± 5.6 days) was shorter than the underweight patient (27.8 ± 17.7 days) and overweight patients (22.4 ± 11.6 days). Intake of patients was generally under the need of their body. BMI status, albumin level, and food i...

Patients with end-stage kidney disease (ESRD) undergoing hemodialysis (HD) tend to have multiple comorbidities, especially cardiovascular disease, mineral and bone disorders which are important factors and contribute to the morbidity and mortality of HD patients. So it is important to know the types of intra-dialysis physical exercises that are safe and effective for HD patients. The type of research analyzed in this journal writing is a randomized controlled trial (RCT) that focuses on interdialysis physical exercise interventions both at home and HD center. With a literature search using PubMed, ScienceDirect, Willey, Proquest and Google Scholar databases. And those who meet the relevant requirements and reviews are: 8. Based on several reviews of intradialytic exercise studies in HD patients, intra-dialysis low intensity strength training is found safe and effective in adults and older. Research shows that doing 30 minutes of intradialytic exercise per session 3 times a week for at least >= 8 weeks is beneficial for HD patients. Regular exercise should be considered as an important therapeutic modality in the care of patients undergoing HD. Strength training improves physical performance, nutritional status and physical activity. But this study needs further research, so that it can contribute to the provision of evidence-based information in applying safe intradialytic exercises and become part of routine dialysis treatment units. ABSTRAKPasien dengan penyakit ginjal stadium akhir (ESRD) yang menjalani hemodialisis (HD) cenderung memiliki beberapa komorbiditas terutama penyakit kardiovaskular, gangguan mineral dan tulang yang merupakan faktor penting dan berkontibusi terhadap morbiditas dan mortalitas pasien HD. Sehingga penting untuk diketahui jenis latihan fisik intra dialisis yang aman dan efektif bagi pasien HD. Jenis studi yang dianalisis pada penulisan jurnal ini adalah adalah randomized controlled trial (RCT) yang berfokus pada intervensi latihan fisik intra dialisis baik yang dilakukan dirumah maupun di pusat-pusat HD. Dengan pencarian literatur menggunakan data base PubMed, ScienceDirect, Willey, Proquest dan Google Scholar. Dan yang memenuhi syarat dan ulasan yang relevan yaitu 8. Dari beberapa ulasan studi latihan intradialytic pada pasien HD, latihan kekuatan intensitas rendah intra-dialisis aman dan efektif pada orang dewasa dan yang lebih tua. Penelitian menunjukkan bahwa melakukan latihan intradialytic selama 30 menit per sesi 3 kali seminggu selama setidaknya >= 8 minggu bermanfaat bagi pasien HD. Olahraga teratur harus dianggap sebagai modalitas terapi penting dalam perawatan pasien yang menjalani