Background Increased workload, lack of resources, fear of infection, and the suffering and loss of residents have placed a significant emotional burden on regulated and unregulated direct care nursing staff (eg, registered nurses, licensed practical nurses, and care aides) in nursing homes (residential long-term care homes). Psychological distress and burnout related to COVID-19 have been cited among direct care staff within nursing homes. Studies have also emphasized the resilience of direct care staff, who, despite the significant challenges created by the pandemic, remained committed to providing quality care. To date, only one nursing home–specific review has synthesized evidence from 15 studies conducted early in the pandemic, which reported anxiety, posttraumatic stress disorder, and depression among direct care staff. Objective The objectives of this systematic review are to (1) synthesize all empirical evidence on the impact of the COVID-19 pandemic on direct care staffs’ mental health, physical health, and work-life outcomes; (2) identify specific risks and protective factors; and (3) examine the effect of strategies or interventions that have been developed to improve these outcomes. Methods We will include all study designs reporting objective or subjective measurements of direct care staffs’ mental health, physical health, and quality of work-life in nursing home settings during the COVID-19 pandemic (January 2020 onward). We will search multiple databases (MEDLINE, CINAHL, Embase, Scopus, and PsycINFO) and gray literature sources with no language restrictions. Two authors will independently screen, assess data quality, and extract data for synthesis. Given the heterogeneity in research designs, we will use multiple data synthesis methods that are suitable for quantitative and qualitative studies. Results As of December 2022, full text screening has been completed and data extraction is underway. The expected completion date is June 30, 2023. Conclusions This systematic review will uncover gaps in current knowledge, increase our understanding of the disparate findings to date, identify risks and factors that protect against the sustained effects of the pandemic, and elucidate the feasibility and effects of interventions to support the mental health, physical health, and quality of work-life of frontline nursing staff. This study will inform future research exploring how the health care system can be more proactive in improving quality of work-life and supporting the health and psychological needs of frontline staff amid extreme stressors such as the pandemic and within the wider context of prepandemic conditions. Trial Registration PROSPERO CRD42021248420; https://tinyurl.com/4djk7rpm International Registered Report Identifier (IRRID) DERR1-10.2196/40390

BACKGROUND Increased workload, lack of resources, fear of infection, and the suffering and loss of residents have placed a significant emotional burden on regulated and unregulated direct care nursing staff (eg, registered nurses, licensed practical nurses, care aides) in nursing homes (residential long-term care homes). Psychological distress and burnout related to COVID-19 have been cited among direct care staff within nursing homes. Studies have also emphasized the resilience of direct care staff, who despite the significant challenges created by the pandemic, remained committed to providing quality care. To date, only one nursing home specific review has synthesized evidence from 15 studies conducted early in the pandemic which found anxiety, post-traumatic stress disorder, and depression among direct care staff. OBJECTIVE The objectives of this systematic review are (1) to synthesize all empirical evidence on the impact of the COVID-19 pandemic on direct care staffs’ mental health, physical health, and work-life outcomes, (2) identify specific risks and protective factors, and (3) examine the effect of strategies or interventions that have been developed to improve these outcomes. METHODS We will include all study designs reporting objective or subjective measurements of direct care staffs’ mental health, physical health, and quality of work-life in nursing home settings during the COVID-19 pandemic (January 2020 onward). We will search multiple databases (MEDLINE, CINAHL, Embase, Scopus, and PsycINFO) and grey literature sources with no language restrictions. Two authors will independently screen, assess data quality, and extract data for synthesis. Given the heterogeneity in research designs, we will use multiple data synthesis methods that are suitable for quantitative and qualitative studies. RESULTS As of Dec 2022, full text screening has been completed and data extraction is underway. The expected completion date is June 30, 2023. CONCLUSIONS This systematic review will uncover gaps in current knowledge, increase our understanding of the disparate findings to date, identify risks and factors that protect against the sustained effects of the pandemic and the feasibility and effects of interventions to support the mental health, physical health, and quality of work-life of frontline nursing staff. This study will inform future research exploring how the healthcare system can be more proactive in improving quality of work-life and supporting the health and psychological needs of frontline staff amidst extreme stressors such as the pandemic and within the wider context of pre-pandemic conditions. CLINICALTRIAL Systematic Review Registration: This review is registered with PROSPERO (CRD42021248420). INTERNATIONAL REGISTERED REPORT DERR1-10.2196/40390