Background Acute kidney injury (AKI) was common in the first two waves of the SARS-COV-2 pandemic in critically ill patients. A high percentage of these patients required renal replacement therapy and died in the hospital. Methods The present study examines the clinical presentation, laboratory parameters and therapeutic interventions in critically ill patients with AKI admitted to the ICU in two centres, one each in India and Pakistan. Patient and outcome details of all critically ill COVID 19 patients admitted to the ICU requiring renal replacement therapy were collected. Data was analysed to detect patient variables associated with mortality. Results A total of 1,714 critically ill patients were admitted to the ICUs of the two centres. Of these 393 (22.9%) had severe acute kidney injury (AKIN stage 3) requiring dialysis. Of them, 60.5% were men and the mean (± SD) age was 58.78 (± 14.4) years. At the time of initiation of dialysis, 346 patients (88%) were oligo-anuric. The most frequent dialysis modality in these patients was intermittent hemodialysis (48.1%) followed by slow low efficiency dialysis (44.5%). Two hundred and six (52.4%) patients died. The mortality was higher among the Indian cohort (68.1%) than the Pakistani cohort (43.4%). Older age (age > 50 years), low serum albumin altered sensorium, need for slower forms of renal replacement therapy and ventilatory support were independently associated with mortality. Conclusion There was a very high mortality in patients with COVID-19 associated AKI undergoing RRT in the ICUs in this cohort from the Indian sub-continent.

Objective: To record the incidence of AKI following acute gastroenteritis and to poor prognostic factors in patients having AKI following gastroenteritis. Methodology: We enrolled 92 cases with above 14 years of age diagnosed to have acute kidnay injury due to gastroenteritis. Detailed history, clinical examination and laboratory investigations were done at admission. Serum creatinine, urea, potassium were done daily. Other investigations done were liver function tests, urine complete examination, serum sodium levels, ultrasound abdomen and renal failure and its associated factors were recorded. Results: We studied 92 patients admitted to our hospital with acute gastroenteritis. Among those 48(54%) patients had AKI whereas 44(46%) patients didn’t developed AKI following acute gastroenteritis. AKI was more common in males(72%) as compared to females(28%). The most common manifestation was oliguria and anuria in( 66%)of the cases, (43%) of the patients having AKI had hypertension and (29%) had DM.(94%) patients were managed conservatively and (6%) required hemodialysis. Conclusion: We concluded that AKI is highly prevalent in patients with gastroenteritis whereas diarrhea is a major risk factor of AKI. Keywords: Gastroenteritis, Acute renal failure(AKI), risk factor