Synthesis of tetrakis(cyclopropylmethyl)methane, a new symmetric product has been described using the radical mediated gem-diallylation of cyclopropylmethyl xanthate as a key step and its single crystal X-ray analysis established its C2-symmetry.

A metal‐free approach for the synthesis of 4‐substituted pyrolo[2, 3‐c]quinoline is reported in this paper. Synthesis of the target molecule started from easily available quinoline and was carried out in five steps. The fused pyrrolo‐quinoline unit was assembled using Bartoli indolization and the crucial final step involving microwave assisted C−N bond formation was carried out by reaction of 4‐chloro‐3H‐pyrrolo[2, 3‐c]quinolines and diverse aliphatic amines, in the presence of N, N’‐diisopropylethylamine (DIPEA). Final molecules were obtained in good yields even in the presence of additional bromine functionality on the quinolines, thus demonstrating the selectivity of the developed coupling procedure and possibility of increasing the product diversity.

First total synthesis of quinoline-serrulatane alkaloid microthecaline A.

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