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In this study an efficient and environment friendly electrochemical sensor has been designed for the analysis of acetaminophen (APAP) drug. Electrochemical impedance spectroscopy, differential pulse voltammetry and cyclic voltammetric techniques were used to demonstrate the fabricated erGO/GCE sensor performance. Voltammetric assessment of acetaminophen drug was done using bare GC electrode, drop-casted GO/GC electrode and erGO/GCE electrochemical sensor. Proposed sensor was precisely validated for APAP detection by differential pulse voltammetric technique. Subsequently LOD, LOQ, sensitivity and linearity were determined and found to be 7.23 nM, 21.909 nM, 20.14 μA nM −1 cm −2 and 0.0219–2.30 μM, respectively. The diffusion coefficient of APAP was determined by chronoamperometry, and it was found to be 2.24 × 10 –5 cm 2 .s −1 . The synthetic and analytical steps were assessed as per the Green Chemistry’s 12 Principles giving a 66 score (acceptable) and 93 score (excellent) for the said steps, respectively. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s11696-022-02628-9.

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