IntroductionBirth weight is described as the primary determinant of the chances of survival among newborns. Low birth weight (LBW) is considered to be a major public health issue, especially among developing countries where poor maternal nutritional status is identified as a cause of both long and short-term adverse consequences. In developing countries, the majority of the LBW infants are born at term but are affected by intrauterine growth restriction, which might have begun early in the pregnancy period. We conducted this study in order to determine the possible effects of the poor nutritional status of mothers on the birth weight of their newborns. However, in disparity to the previous literature, our study evaluated unpredictable results. MethodsThis is a cross-sectional study that was conducted at two tertiary care teaching hospitals from November 2020 to April 2021 in order to determine the possible effects of the poor nutritional status of mothers on the birth weight of their newborns. 156 women both primigravida and multigravida of ages between 15 and 50 years and those who delivered low birth weight (LBW) babies of either gender at term (37-40 weeks of gestation) were included. For all mothers who delivered LBW (<2500 g) at term, their mid-upper arm circumference (MUAC) was measured by inelastic tape. Mothers with MUAC less than 21 cm were considered malnourished. ResultsA total of 156 study participants were included in the study, with majority (n=112, %=71.8%) of them between the ages of 20 and 30 years. The mean age of all included participants was calculated to be 25.96±4.54 years (ranging from 18 to 38 years). Prevalence of maternal malnutrition was observed in 41 (26.3%) of the included women who delivered LBW babies, in contrast to high prevalence rates in previous literature. ConclusionsIn contrast to the previous literature, our study has shown that the nutritional status of mothers has no significant impact on the weight of neonates and the majority of neonates in our study were not severely low weight

The objective is to study the demographic and geographical factors that increase the risk of colorectal cancer (CRC) in inpatients with ulcerative colitis (UC) and evaluate the mortality risk and hospitalization outcomes in terms of length of stay (LOS) and cost of care in patients with CRC in UC. MethodsWe conducted a cross-sectional study using the nationwide inpatient sample (NIS, 2019). We included 78,835 inpatients (age 15-65 years) hospitalized on emergency-based admissions with a primary diagnosis of UC. The study sample was divided by the presence of CRC. Categorical and continuous data were analyzed using Pearson's chi-square test and independent-sample t-test respectively. Independent binomial logistic regression models were used to evaluate the odds ratio (OR) of predictors associated with CRC in patients with UC compared to non-CRC. ResultsThe prevalence of CRC in inpatients with UC was 0.2%, and the mean age for admission of patients with UC with CRC was 49.6 years (SD ± 10.29). A directly proportionate relationship exists between increasing age and the risk of CRC in UC inpatients with 10 times higher odds seen in 51-65 years of age (OR 10.0, 95% CI 5.11-19.61). Males (OR 2.15, 95% CI 1.49-3.08) and Hispanics (OR 1.69, 95% CI 1.04-2.74) are at higher odds for CRC compared to their counterparts. Acquired immunodeficiency syndrome (AIDS) was associated with increased odds (OR 6.23, for CRC in UC inpatients. There existed an increased association for CRC in UC inpatients with complicated hypertension, and alcohol and drug abuse but was statistically non-significant. As per the adjusted regression model, CRC in UC inpatients increased the risk of in-hospital mortality (OR 41.09,. ConclusionsCRC was more prevalent in middle-aged Caucasian males with UC and those with chronic comorbidities including complicated diabetes and hypertension, alcohol abuse, and AIDS. Patients with UC and AIDS were found to have greater odds of developing CRC. A high index of clinical suspicion is needed in the management of these patient groups as the inpatient mortality risk was higher in UC inpatients with CRC.

To delineate the differences in demographic characteristics and hospitalization outcomes in patients with acute myocardial infarction by comorbid acute kidney injury (AKI) and to explore the risk factors for inhospital mortality due to AKI in acute myocardial infarction (AMI) inpatients. MethodsWe conducted a retrospective cross-sectional study using a nationwide inpatient sample and included 77,585 adult inpatients with AMI and further divided by the presence of a co-diagnosis of AKI. A logistic regression model was used to evaluate the odds ratio (OR) of the association between in-hospital mortality and AKI and other comorbidities. ResultsThe prevalence of AKI in AMI inpatients during hospitalization was 11.69%. Among AMI inpatients with AKI, it was prevalent in males (73.9%) and whites (48.8%). Patients with AKI had a higher prevalence of complicated comorbid hypertension (58.7%), diabetes with complications (34.8%), cardiogenic shock (17.4%), and drug abuse (12.3%). Male patients had lower odds of in-hospital mortality (OR 0.69; 95% Cl 0.61-0.79) compared to females. Hispanics had a higher association with mortality (OR 1.45; 95% Cl 1.21-1.74) than whites and other races/ethnicities. Patients who developed cardiogenic shock were at 17 times higher odds of in-hospital mortality (OR 17.25;, followed by AKI (OR 4.64; 95% CI 4.06-5.31), and alcohol abuse (OR 1.29; 95% CI 1.03-1.64). The in-hospital mortality rate among AMI inpatients with AKI (7.6%) was significantly higher compared to that seen in the non-AKI cohort (0.9%). ConclusionAMI inpatients with AKI during hospitalization was prevalent in males and whites. Among the demographic risk factors, females and Hispanics had a higher likelihood of in-hospital mortality during the inpatient management of AMI. Cardiogenic shock and AKI increased the odds of in-hospital mortality compared to other comorbidities in AMI inpatients.

The objective is to study factors that increase the likelihood of acute myocardial infarction (AMI) in hospitalized adult non-elderly patients with pneumonia compared to other medical inpatients and to understand the utilization rate of percutaneous coronary intervention (PCI) for AMI in inpatients with pneumonia and its related impact on hospitalization stay and cost. A population-based study was conducted using the Nationwide Inpatient Sample (NIS, 2019) with adult non-elderly inpatients (age 18–65 years) with a medical condition as their primary diagnosis and a co-diagnosis of pneumonia during hospitalization stay. This study sample was divided by the primary diagnosis of AMI versus other medical conditions (non-AMI). A logistic regression model was used to evaluate the odds ratio (OR) of predictors associated with AMI in patients with pneumonia. The results showed a direct relationship between increasing age and the likelihood of AMI in pneumonia inpatients with three times higher odds seen in 51–65 years of age (OR 2.95, 95% CI 2.82–3.09). The comorbidities included complicated hypertension (OR 2.84, 95% CI 2.78–2.89), diabetes with complications (OR 1.27, 95% CI 1.24–1.29), and drug abuse (OR 1.27, 95% CI 1.22–1.31) that increased the likelihood of AMI-related hospitalization. The utilization rate of surgical treatment (PCI) was 14.37% for the management of AMI in inpatients with pneumonia. Inpatients co-diagnosed with pneumonia and comorbidities such as hypertension and diabetes were more likely to be hospitalized for AMI. These at-risk patients should be considered for early risk stratification. Utilization of PCI was associated with a lower in-hospital mortality rate.

Thyroid storm, also known as thyrotoxic crisis is an acute, rare life-threatening condition of thyroid gland; possessing 100% mortality when it’s not treated in time. Thyroid storm coexisting with respiratory failure further can contribute to this mortality. Respiratory collapse can be irreversible. This is an endocrine emergency first described in 1926.  This is important to recognize it early and treat to reduce mortality.   Herein, we review a case of 75 years of male who developed Cardio-respiratory failure while he was manifesting clinical features thyroid storm.