Objectives: To compare the effectiveness of 2% Diltiazem ointment with 0.2%Glyceryl trinitrate ointment. Place & period: The study was conducted in surgical units,Bahawal Vicotria Hospital, Bahawalpur, Pakistan from 01-01-2016 to 31-12-2016. Material &Method: In this prospective comparative study, 160 patients with anal fissure were equally&randomly divided in two group A (received 2%diltiazem ointment) & group B (received 0.2%Glyceryl trinitrate ointment). The ointment had to be applied to anal verge twice daily for 6-8weeks. Assessment was done at 2nd, 4th & 6th weekends for fissure healing, pain relief & sideeffects. Results: Complete fissure healing was observed in 80%of patients in group A & 70% ingroup B (P<0.15). Pain response was good & was fairly similar in both the groups. Headacheoccurred in 5% in group A & 20% in group B (P<0.002). Mean time taken for healing of fissurein group A was 5.5±0.28 weeks & in group B was 5.8±0.32 weeks (P< 0.237). Recurrence ratewas 7.5% in group A & 17.5% in group B. Conclusion: Topical Diltiazem is preferred to topicalGlyceryl trinitrate in the treatment of acute & chronic fissure, because it is associated with a fewside effects.

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