Conventional chemotherapy substances are associated with mild to severe side effects that affect both healthy and cancer cells. It is presumed to improve therapeutic efficacy in coexistence reducing chemotherapy's side effects. Fucoidan is an anticancer bioactive compound derived from Sargassum sp. that has low cytotoxic activity. The purpose of this study was to explore the effectiveness of anticancer activities of fucoidan from Sargassum sp. against breast cancer then analyze the suitability of nano transdermal patch of fucoidan and blueprint the long-term research design of nano transdermal patch as a chemoprevention agent in the chemotherapeutic management of breast cancer. This research was performed through a literature study and in silico study by imposing carbonic anhydrase IX (CA IX) as a marker of hypoxia and metastatic state of cancer cells. The results showed that the fucoidan from Sargassum sp. effectively induced apoptosis and prevented metastasis of breast cancer cells through the Bcl-2, Bcl-w, and bad pathways. Fucoidan, in addition, was predicted to inhibit CA IX by Glu4 Glu5, Leu7, Pro8, and Asp6 residues. Therefore, the delivery of fucoidan is favored to have a local effect on the site of breast cancer cells by nano transdermal patch preparations using fucoidan nanoparticle polymer. Further nano transdermal patch development as a treatment for breast cancer is suggested through the stages of formulation optimization, optimum formula activity testing, patent filing, and distribution in health services.

The energy crisis is a crucial problem as evidenced by data from Indonesia Outlook Energy which states that 88% of the total electricity is comes from fossil fuels whose reserves continue to decline. This encourages the government to suppress the use of fossil fuels and look for alternative renewable energy sources. Indonesia has a promising livestock sector but its utilization is still not optimal. One of those is cow fecal waste that generally has been used as potential biogas. It is necessary to have a program to optimize the utilization of cow feces as biogas in villages and integrate it with the sociopreneurship-based energy-concept independent village. The purpose of this paper is to analyze the potential of cow fecal waste as an alternative energy source based on community conditions, analyze the implementation of energy-concept independent village, sociopreneurship basis and the financial aspects of the program, as well as implementation strategy and sustainability of the program to achieve SDGs target. The research was conducted using data collection methods, data processing, and data analysis. Energy-independent village is able to occupy its energy consumption by optimizing the potential from indigenous product. This program integrates a supporting system consisting of a Special Team, cow farmers, ROFES (House of Feces), and GUBAS (Village Biogas Warehouse). The implementation of this research program includes pre-production, production, and post-production stages. This program is expected to be able to contribute to fulfill the energy needs of the village by optimizing cow fecal waste and supporting the SDG's targets.

Type 2 diabetes mellitus (T2DM) is a chronic disease that poses a significant global health issue. Acarbose is a commonly given drug to treat diabetes, which works as an inhibitor of polysaccharide-degraded enzymes. However, acarbose has side effects that cause indigestion, diarrhea, flatulence, nausea, and vomiting. On the other hand, Aloe vera contains compounds that have been proven to have antidiabetic activity by reducing glucose levels in the blood and increasing insulin production and sensitivity to insulin by in vitro study.