Biocatalytic potential of a new wild-type amine dehydrogenase used in an enzyme-catalyzed synthesis of an enantiomerically pure primary amine.

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A number of aryl building blocks for the synthesis of two xanthomonadin natural product pigments, as well as a related analogue, were accessed using a divergent hydroboration/bromoboration approach from a key alkynyl intermediate. A new approach towards substitution patterns around the ring was adopted following the isolation of an unexpected regioisomer from the bromination reaction. Potential coupling reactions onto these building blocks were explored, with a successful Sonogashira coupling performed on the key alkynyl intermediate, and with the key debrominated styrenyl boronate ester intermediate functionalised both by preliminary Suzuki–Miyaura coupling and by iododeboronation/Heck–Mizoroki coupling. Coupling reactions with brominated styrenyl intermediates proved much more challenging due to the instability of the intermediates to cross‐coupling, but some studies have shown promise.

1998 substitution reactions substitution reactions O 0040 -060Palladium-Catalyzed Cross-Coupling Reactions in Supercritical Carbon Dioxide.-The higher conversions with TBP as a ligand (compared to other ligands tested) appear to arise from the better solubilization of the catalytically active palladium-phosphine complexes.-(MORITA, D. K.; PESIRI, D. R.; DAVID, S. A.; GLAZE, W. H.; TUMAS, W.; Chem. Commun.