Background: Follicular adenoma is a benign tumor enclosed by a capsule with follicular differentiation, more common in women and usually occurs in adulthood, and is more common in iodine deficiency. The average tumor size is 1-3 cm. Follicular neoplasms do not have features of papillary thyroid carcinoma and no capsule and/or vascular invasion were found. This study aims to evaluate the characteristics of follicular adenoma patients at H. Adam Malik General Hospital, Medan, during the 2017-2020 periodMethods: This study is a descriptive study with a cross-sectional approach on 31 samples based on medical record data diagnosed as follicular adenoma. After reviewing the slides, 23 samples were obtained that met the inclusion and exclusion criteria. Samples were assessed according to age, sex, tumor size, number of nodules, growth patterns, and histopathological variants. Data were analyzed using SPSS version 26 for Windows.Results:  Cases of follicular adenoma at H. Adam Malik Hospital Medan during 2017-2020 with an average age of 46.7 years. The youngest age was 20 years and the oldest age was 71 years, with the highest age group being 50-59 years (26.1%). Most gender was female (87.0%) than male (13.0%). The most common tumor size was above 4 cm (69.6%). The highest number of nodules was found in 1 nodule (solitary or unilateral) (52.2%). The most common growth pattern in microscopic preparations was macrofollicular adenoma (65.2%), with the most histopathological variant being conventional follicular (91.3%).Conclusion: Benign lesions such as adenomas are often misdiagnosed due to the lack of further studies on the histopathological criteria. Follicular adenomas can be treated with lobectomy and have a good prognosis if diagnosed early and with proper treatment.

Background: Colorectal adenocarcinoma is a malignancy of the large intestine (colon and rectum) of epithelial origin, ranks third in the world, and the second leading cause of cancer death. The prognosis can be assessed based on the reaction of the tumor microenvironment that plays a role in the stage of cancer development. Immunohistochemical examination of Fibroblast Activation Protein (FAP) as well as an assessment of grading and how the ratio between the extent of tumor and stroma (Tumor-Stroma Ratio) has recently been one of the prognostic predictors of colorectal adenocarcinoma. Objective: To analyze the relationship of immunohistochemical expression of Fibroblast Activation Protein (FAP) with histopathological grading and Tumor-Stroma Ratio (TSR) in colorectal adenocarcinoma. Materials and Methods: 32 samples in the form of histopathological slides from surgical tissue with a diagnosis of colorectal adenocarcinoma, reviewed slides and assessed for grading and TSR scores, then performed immunohistochemical staining of Fibroblast Activation Protein (FAP) and assessed the expression, then analyzed for correlation between variables using the Somers'd correlation test. Results: The most histopathological grading distribution was low grade, the highest TSR was TSR-High, and the highest FAP expression found was strong expression. Based on the Somer's d correlation test, it was found that there was a significant correlation between FAP expression and grading (p=0.037) and there was no significant correlation between FAP expression and TSR (p=0.244). Conclusion: The tumor microenvironment is one of the prognostic predictor factors in colorectal adenocarcinoma patients, should be reported in the routine pathology report and further investigated how the stromal component and the role of FAP expression to open the possibility of other targeted therapies.