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Aim To investigate the presence and impact of self-sacrifice within the nursing profession. Background Evidence suggests the existence of a culture of self-sacrifice within nursing, but its potential detriments to the profession have not been explored. Design A qualitative descriptive approach was used. Methods Semistructured interviews were conducted with 10 practicing nurses to explore the existence and potential implications of a self-sacrificing culture within nursing. Results All participants reported self-sacrifice within the nursing profession as the result of the prevailing stereotypical image of the “ideal nurse,” leading to job dissatisfaction, presenteeism, and burnout. Younger nurses reported being less willing to self-sacrifice and consequently felt unsupported by management and senior staff, resulting in job dissatisfaction and intent to leave their job. Conclusion A culture of self-sacrifice within the nursing profession may lead to job dissatisfaction, presenteeism, burnout, and retention problems, especially for younger nurses. A self-sacrificing image of nursing may also deter potential recruits from exploring a career in the profession.