A Hermite differential reproducing kernel (DRK) interpolation-based collocation method is developed for solving fourth-order differential equations where the field variable and its first-order derivatives are regarded as the primary variables. The novelty of this method is that we construct a set of differential reproducing conditions to determine the shape functions of derivatives of the Hermite DRK interpolation, without directly differentiating it. In addition, the shape function of this interpolation at each sampling node is separated into a primitive function possessing Kronecker delta properties and an enrichment function constituting reproducing conditions, so that the nodal interpolation properties are satisfied for the field variable and its first-order derivatives. A weighted least-squares collocation method based on this interpolation is developed for the static analyses of classical beams and plates with fully simple and clamped supports, in which its accuracy and convergence rate are examined, and some guidance for using this method is suggested.