The CB PAM GAT229 reduces IOP in ocular hypertensive mice and enhanced CB-mediated IOP reduction when combined with subthreshold CB orthosteric ligands in normotensive mice. Administration of CB PAMs may provide a novel approach to reduce IOP with fewer of the disadvantages associated with orthosteric CB activation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.