Burn injuries and their treatment is an important medical and social problem. Compartment syndrome is a serious complication of deep circular burns, which causes increased subfascial pressure and local tissue ischemia with the development of intercellular interstitial edema and a significant rise of intra−tissue pressure, which exacerbates tissue blood supply, enhancing the tissue hypoxicity. Treatment is performed by necrotomy, which due to decompression helps to reduce intra−tissue pressure and reduce the scale of necrobiotic processes in damaged tissues. To develop a method to treat deep subfascial burns, a study was conducted in 15 patients. Dynamic monitoring of tissue pressure in the fascial sheaths of each muscle allowed to determine the direction and degree of degenerative−destructive changes caused by zonal microcirculation disorders, increasing edema, hypoxia, ischemia and necrosis of individual muscle fibers, which helped to determine the need for surgery. The method of treatment included decompression necrofasciotomies with opening of zonal fascial−aponeurotic muscular bed−cases of the first order in the paranecrosis areas; general anti−shock and detoxification therapy; local ozone therapy with a complex of cytoprotectants and antioxidants; necrectomy and autodermoplasty. According to the results of the study, it is concluded that an important place in treatment of the compartment syndrome in the patients with deep burns is the objectification of intra−tissue pressure. The method of determining the dynamics of compartment syndrome and surgical tactics will allow preserving the viability of a significant part of the damaged muscle mass, reduce the volume of tissues that underwent necrectomy, restore the skin timely. Key words: burns, compartment syndrome, intratissue pressure, surgical treatment.

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Summary. Objective. Improvement of the diagnosis of compartment syndrome depending on the time of thermal injury and the establishment of indications for draining operations. Materials and methods. Interstitial pressure was studied in 66 victims who were admitted to the burn center in the first 24 hours after the injury. The patients were divided into groups depending on the relative extent of the lesion and the length of hospitalization. The results of the study and their discussion. Upon admission of the patient to the department, a thorough sanitation of the burn surfaces was performed with antiseptic solutions (chlorhexidine, dekasan). In the burn area, the interstitial pressure was measured in all muscle groups deeper than the superficial fascia with a Kompartment druck Monitor System (MIPM Mammen dorfer Institut für Physik und Medizin Gmbh) apparatus for measuring interstitial pressure. Depending on the level of interstitial pressure, patients underwent conservative drug and infusion therapy aimed at reducing edema and hypoxia of damaged tissues. In the case of critical indicators of interstitial pressure, an urgent surgical intervention was performed for the purpose of decompression. When assessing the dependence of the pressure level in the tissues on the timing of burns, there is a clear dependence in all observation groups: late hospitalizations are accompanied by a large increase in pressure, the level of circular location of burns on the extremities is of great importance for high blood pressure. Conclusion. It has been determined that objectification of the diagnosis of the compartment syndrome in order to prevent ischemic tissue damage plays an important role in deep and borderline burns. Clinical indicators of tissue pressure in deep and borderline burns have been established, depending on the time of thermal injury, which allows the diagnosis of compartment syndrome and the establishment of indications for drug, infusion therapy and urgent drainage operations.

Compartment syndrome is one of the complications of tissue damage of various origins, the basis of which is the compression of blood vessels and disruption of blood supply to tissues due to an increased local pressure in the closed space of the fascial sheath. The consequences of compartment syndrome can be local and general. An effective treatment of compartment syndrome in burns is to perform a necrotomy, which due to decompression helps to reduce intra−tissue pressure and diminish the scale of necrotic changes in tissues. In order to morphologically evaluate the effectiveness of necrofasciotomy, as well as the one in combination with infiltration of ozonated saline area of deep circular skin burns with underlying tissues, complicated by compartment syndrome, an experimental study was conducted. Circular deep burns, complicated by the formation of compartment syndrome, were simulated in 18 WAG rats. To reduce the pressure in the burned and surrounding tissues, surgical interventions such as necrofasciotomy were performed, which provided a notable reduction in pressure. In parallel, infiltration of damaged tissues with ozonated saline was performed, which was bubbled for 15 minutes at a dissolved ozone concentration of 4.0±0.2 mg / l, which improved microcirculation and reduced tissue hypoxia. The findings indicate that the compartment syndrome is characterized by a significant severity of general pathology. Performance of necrofasciotomy of a burn wound with its infiltration by ozonated physiological solution in comparison with just necrofasciotomy has more positive medical effect, and efficiency of these medical measures increases when they are performed at early terms (day 1) of formation of a burn wound in comparison with late terms (day 3). Key words: burns, surgical treatment, compartment syndrome, histological examinations.

For the local treatment of burns, numerous drugs have been proposed with a tendency to expand the range of drugs. In order to establish the effectiveness of Wundehil ointment in the treatment of superficial burns and to determine the optimal methods of its application, the results obtained in the patients with second−grade burns were analyzed. Clinical evaluation of treatment was performed on the basis of visual control of the wound process, determination of the amount and nature of exudate, the timing of epithelialization of superficial burns. The dynamics of the wound process was observed by cytological examination. In the preparations, which were examined by immersion microscopy, the cell composition was studied to determine the type of cytogram according to the generally accepted classification. The type of cytogram in the patients was characterized as inflammatory. Among the cell elements in the smear, segmental neutrophilic granulocytes, monocytes in small numbers, and single lymphocytes predominated. Signs of phagocytic activity were recorded, and neutrophilic granulocytes with intracellular arrangement of microorganisms were detected. On the 7th day after the injury, the inflammatory type of cytogram was recorded in smears−imprints in 3 patients, inflammatory−regenerative were found in 6, regenerative ones were revealed in 14. On the 10th day only 2 patients had an inflammatory−regenerative type of cytogram. The obtained data indicate that the "Wundehyl" drug on a lipophilic basis with the content of components of natural origin meets the requirements for a local treatment of burns. The use of this ointment in patients with second−degree burns reduces the severity of the inflammatory reaction, has a stimulating effect on reparative processes in the burn wound, prevents mechanical damage during dressings and reduces the duration of epithelialization in second−grade burns. Key words: burns, local treatment, cytological examinations, "Wundahyl" ointment.