About 18.8 million American adults suffer depressive disorders that may occur with anxiety and substance abuse. Tetrahydrocannabinol (THC), a compound in marijuana, is a cannabinoid chemical that binds to and activates cannabinoid receptors (CB1) in the pre‐synaptic cell membrane as part of neuron‐to‐neuron transmission in the endocannabinoid system (ECS). Glutamate in the pre‐synaptic cell is released and binds to the post‐synaptic cell triggering the synthesis and release of 2‐arachidonoylglycerol (2‐AG). 2‐AG returns to the pre‐synaptic cell binding to and activating CB1 receptors. THC mimics 2‐AG action, and is used to study the ECS retrograde signaling system and its effect on appetite and mood. A protein from the pre‐synaptic cell, monoacylglycerol lipase (MAGL), hydrolyzes 2‐AG into arachidonic acid (AA) and glycerol controlling 2‐AG levels. When MAGL is hyperactive, too much 2‐AG degrades, which is hypothesized to contribute to depression and anxiety. Hypoactive MAGL activity creates an excess of 2‐AG. It is hypothesized that this can contribute to obesity and addictive behaviors. The Brown Deer Students Modeling a Research Topic Team, in alliance with MSOE, built a MAGL model using a 3D printer. Study of MAGL crystal structure may provide the key to regulating MAGL's enzymatic activity leading to therapies that will prevent neurodegenerative disorders. Supported by a grant from NIH‐NCRR‐SEPA