Most developing countries including Lesotho, faces a major challenge of creating jobs for their high education graduates. This matter hard presses policy makers to advocate for training which equips graduates to venture into self-employment for job creation. This study therefore intended to establish students' opinions regarding self-employment opportunities in agriculture. The key objectives were: to describe students' knowledge of potential self-employment opportunities in agriculture; to assess students' willingness to engage in self-employment in agriculture; to identify factors constraining graduates from venturing into self-employment in agriculture. Sixty-six final year students in the faculty of agriculture were purposefully selected for the study. A structured questionnaire was used as a data collection instrument for this study and data were analysed descriptively using statistical indicators including percentages, mean and standard deviation. Findings revealed that Students perceived that agriculture has a potential of creating employment for huge number of people and they are willing to undergo agri-business after completion of their studies. It is therefore recommended that practical agribusiness training be included in undergraduate agriculture curriculum to entrench this skill. The government should support agricultural graduates by addressing all the identified constraints such as marketing, input supply, credit, training, extension services and poor storage facilities. Keywords: Students' opinions, Self-employment, Agriculture, Agri-business.