Introduction. One of the main unresolved problems in coronary surgery has been the search for an “ideal” graft for coronary artery bypass surgery. Surgical procedures with the use of artificial circulation can lead to high incidence of postoperative complications compared to operations on a beating heart. The aim. To study the results of total arterial myocardial revascularization on a beating heart and to evaluate the medium-term outcomes in patients with coronary heart disease. Materials and methods. Ninety eight patients with coronary heart disease were treated from 2009 to 2013. The patients underwent total arterial myocardial revascularization on a beating heart using only arterial grafts: those obtained from internal thoracic artery, radial artery, and right gastroepiploic artery. Results and discussion. No deaths were observed in the postoperative period. In 91 (92.8%) patients, the postoperative period was uneventful. After 5 years of follow-up, clinical and non-invasive methods of examination revealed no coronary circulation disorders. Conclusions. Our clinical experience showed promising short- and medium-term results. The technique of total arterial myocardial revascularization on a beating heart is a good alternative to operations performed under the condition of artificial circulation.

Purpose of the study. Determination of transplantation efficiency of cord blood stem cells (CB SC) for damage to the myocardium and assessment of the repair of its disturbed functions in the experiment. Materials and methods. The experiment was conducted on mice of the FVB line at the age of 5 months, with a body weight of 25–30 g. Animals were divided into experimental groups of 5 animals in each. The animals of the study group were derived from the experiment before the SC suspension injection, after 2 days, 4 and 8 weeks after cell transplantation. Results. Analysis of morphofunctional changes after the introduction of cord blood cells in 4 and 8 weeks compared to the original state (3 weeks after modeling of the isoproterenol induced myocardial injury model) has established a clear tendency to improve the investigated parameters. The confirmed phenomenon of self-referral of cord blood nto the lesion zone proves the expediency of transplantation by intravenous injection of a suspension of CB SC. It has been established that transplantation of CB SC causes a temporary deterioration of morphofunctional features, which may be a manifestation of the body's response to xenotransplantation. The CB SC transplantation has a positive effect on the isoproterenol-induced myocardial injury model. Conclusions: 1. Accumulation of CBSC in the zone of injury after transplantation, proved by experimental research. 2. CB SC transplantation accelerates the processes of myocardial regeneration on the model of injury in laboratory animals. 3.Intravenous injection of the CB SC suspension to the models of myocardial injury proved to be effective. 4. The experimental results obtained can serve as the basis for further clinical studies in patients with heart failure. Keywords: stem cells, transplantation, model injury, umbilical cord blood.

Introduction. Aortic valve disease is often combined with the ascending aortic aneurysm. According to a number of authors, the frequency of the diagnosis varies from 9 to 50%, and the condition requires one-stage surgical correction. Typically, in these cases, mechanical or biologic prostheses are used. The Ozaki procedure allows such operations to be performed without replacing the aortic valve with an artificial prosthesis. The aim. To analyze the results of aortic valve reconstruction using the Ozaki technique combined with ascending aortic aneurysm repair. Materials and methods. The article describes the first experience of treatment of 12 patients with aortic valve disease and ascending aortic aneurysm. All the patients underwent Ozaki procedure modified by J. Benedik with surgical correction of aneurysm of the ascending aorta and the aortic arch. Results and discussion. No deaths were observed in the postoperative period. There was no conversion to aortic valve replacement. Ultrasound imaging after 3 and 6 months revealed no aortic valve dysfunction. Clinically, patients’ well-being was satisfactory and they returned to normal life. Long-term results of these operations interventions require further study. Conclusions. Our first clinical experience showed promising short- and medium-term results. The indications for aortic valve reconstruction are the same as those for valve replacement with a bioprosthesis. Ozaki procedure can be successfully combined with ascending aortic aneurysm repair. The main advantage is the absence of a frame that does not narrow the opening area of the valve and preserves the aortic root function, which is very important for patients with a narrow aortic root.