With the prohibition of the use of Antibiotic growth promotors (AGP) used in animal feed, especially in broilers, the use of feed additives such as herbs, probiotics, prebiotics, synbiotics or mixtures of some of these ingredients is currently widely used as feed replacements for AGP substitutes. One of the commercial feed additives that contain combinations herbal and probiotics is Promix®. In broiler maintenance, one vaccine that must be given is Newcastle Disease (ND) vaccine. The purpose of this study was to determine the role of supplementation of commercial feed combination of herbs and probiotics in broilers given ND vaccines. A total of 42 broilers were divided into two, group A (vaccinated with ND) and B (not vaccinated ND), each with 21 heads. Group A is divided into groups A1, A2 and A3 each with 7 heads. The A1 group is given only basal feed; A2 basal feed and AGP; A3 basal feed and Promix®. Group B is divided by B1, B2 and B3 same as group A before. Broilers are maintained for 5 weeks and weighing each week. All data obtained were statistically analyzed using One Way ANOVA and continued with Duncan's post hoc test. The results of this study were that the group of chickens given the ND vaccine and given supplements of Promix® had greater weight gain (P˂0.05) compared to the AGP and basal groups in the fifth week while in the group of chickens that were not given the ND vaccine but given supplement Promix® feed had greater weight gain (P˂0.05) compared to the AGP and basal groups in the fourth week. In the fifth week there was no significant difference (P˂0.05) between all feed groups in the group not given the ND vaccine. The conclusion of this study that feed additives contain combinations herbal and probiotics can replace AGP as feed additive in broiler. By giving ND vaccine the weight gain of the feed group plus Promix® showed a significant increase in weight gain.

One of the feed additives that have long been used is Antibiotic Growth Promoter (AGP). But nowadays, the use of AGP as a growth promoter has been banned because it has negative impacts such as antimicrobial resistance. Campylobacter jejuni is a pathogenic bacterium that often infects birds, especially broilers. This research aims to investigate the role of synbiotic composed of a prebiotic, and Saccharomyces sp. and Lactobacillus sp. as probiotics (commercial products) in performance of broilers challenged with C. jejuni as a substitute for AGP. Twenty-one Day Old Chicks (DOC) of Cobb-strain broilers were divided into three groups, each consisting of 7 chicks. Group I was given basal diets, group II was given basal diets and AGP (with 250 g/ton of enramycin), and group III was given basal diets and synbiotic (100 gram/100 kg). C. jejuni challenge test was carried out at the 3 rd week. The results suggested that at week 4, group III showed more and significantly different body weight from that of group I, but it did not differ significantly from that of group II. Similarly, at week 4 the weight gain of group III was higher and significantly different compared to that of group I, but did not differ significantly from that of group II. Also, the carcass percentage at week 5 did not differ significantly among the groups, but group III had a higher percentage of carcasses than groups I and II. The addition of synbiotic can replace AGP as a feed additive because it can improve the performance of broilers challenged by C. jejuni.

The use of probiotics as feed additives in farms has been widely known both at a small and large scale. As a substitute for the Antibiotic Growth Promoter (AGP) that has been banned for animal feed, probiotics are used in broilers feeds to improve their performance. Campylobacter jejuni is a type of pathogenic bacteria that often infect birds, especially broilers, and reduce broiler's performance. This study aims to reveal the role of probiotics in the performance of broilers infected by Campylobacter jejuni. A total of 21 broiler Day Old Chicks (DOC) were divided into 3 groups of 7 with different diets: Group K as the control group were given basal diet, Group BA were given a mixture of basal diet and AGP, and Group BP were given a mixture of basal diet and probiotics. This treatment was implemented for 5 straight weeks. In week 3, a Campylobacter jejuni challenge test was conducted using body weight (BW), body weight gain (BWG), and carcass percentage (CP) as the performance parameters. In terms of BW, from week 1 to week 3 no significant differences were found among the groups. In week 4, however, Group BP had a significantly higher BW that Group K, but insignificantly higher than Group BA. In terms of BWG, from week 1 to week 3 there was also no significant differences among the groups. However, in week 4, BWG in Group BP was found to be significantly higher than that of the other two groups. Finally, in terms of CP, Group BP was found to have higher CP than the other two groups, although the difference is not significant. These results show that probiotics can improve broilers' performance by suppressing Campylobacter jejuni infection.

Feed is the main requirement for broilers farms. However, continuous use of AGP can cause antibiotic resistance in poultry and humans. The effectiveness of feed additives in preventing some disease agents has not been much scrutinized. Among the diseases that often arise is Salmonellosis. This study aims to inspect the role of synbiotics consisting of prebiotics and Saccharomyces sp. and Lactobacillus sp. as the probiotics (commercial product) on the performance and blood values of broilers challenged with Salmonella enteritidis. A total of 36 Cobb-strain DOCs were divided randomly into three groups of 12 with different diets. Group I was given broiler comercial feed, Group II was given comercial feed + AGP (enramycin dosage 250 g/ton), and Group III was given broiler comercial feed + Synbiotics (dosage 100 g/100 kg). Each of the three groups is then further divided into two groups of six, one of which is challenged with Salmonella enteritidis on day 22 (1 x 10 9 CFU/mL) for peroral. Vaccines were then given to all groups: ND + IB on day 7, IBD on day 14, and ND booster on day 18. Blood was collected on day 21 and 35, and body weights were taken every week until week 5. The results of this study showed slight differences in the weight gain amongs the groups, with Group III and group II gaining slightly more weights than Group I. The groups that were challenged with Salmonella enteritidis gained less weight compared to the groups that were not challenged in all groups. No significant difference in blood values was found among the groups. Group II and Group III showed slighty better blood values compared to Grup I. It is concuded, then, that the use of synbiotics (commercial product) as feed additives can replace antibiotic growth promotor (AGP) because the results are almost the same.

The prohibition on the use of Antibiotic Growth Promoter (AGP) causes the use of probiotics, herbs, enzymes and organic acids as an alternatives to AGP. This study aimed to determine the role of combination of probiotic and herbs in commercial feed additives on broiler performance. Sixty day-old male broiler were divided into 3 groups where each group consisted of 20 chickens with 4 replication each group. Group I was given commercial feed, group II was given commercial feed + AGP and group III was given commercial feed + combination of probiotics, herbs, enzymes and organic acids. All chickens were kept for 5 weeks. Body weight gain (BWG), body weight (BW) and Feed Convertion Ratio (FCR) were calculated every week. Carcass percentage was calculated at week 5. The results obtained from BWG and BW on group III at weeks 4 and 5 weeks were higher and significant difference (P<0.05) compared to groups I and II. The percentage of carcasses between groups did not have a significant difference (P>0.05). FCR values in group III from week 1 to weeks 5 were lower than groups I and II. The use of combination of probiotics, herbs, enzymes and organic acids has proven to have a good role on broiler performance so that it can replace AGP as a feed additive on broiler.