Mixed cryoglobulinemia is the most common extrahepatic manifestation of chronic HCV-infection. Cryoglobulinemic syndrome characterized by typical clinical triad (skin purple, severe weakness, arthralgia) and possible multiple organ lesions. In chronic HCVinfection imbalance of pro-and anti-inflammatory cytokines is established with advantage of anti-inflammatory cytokines. This imbalance increases in case of severe liver fibrosis. The
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