Introduction: Transvaginal scan is considered as the baseline investigation in women with infertility. Saline infusion sonography is used to study the distended uterine cavity and provides adequate visualisation of the same. This study is performed to assess the role of SIS in women with infertility and to compare its ability in identifying endometrial pathology with that of routine transvaginal sonography. Materials and Methods: In this prospective study, we studied 20 women who attended the infertility clinic in our hospital. All were subjected to routine transvaginal scan followed by saline infusion sonography after obtaining consent for the procedure. All these 20 women also underwent diagnostic hysteroscopy for evaluation of endometrium. Results: The findings noted with transvaginal scan and SIS were analysed and compared with hysteroscopy findings. Endometrial polyp was identified in 8 patients and rest 12 were found to have normal endometrium in Transvaginal scan. 8 women were found to have polyp, 1 with synachiae and rest 11 with normal endometrial cavity during saline infusion sonography. However hysteroscopy showed polyp in 8 and synechiae in 1. The sensitivity of SIS in identifying endometrial pathology in infertile women was better than that of TVS. Specificity remains same for both modalities. Polyps were better identified and demonstrated with SIS, however both modalities were not very efficient in identifying synachiae. Conclusion: Saline infusion sonography, being an outpatient procedure requiring no anaesthesia and cost effective, can be used confidently to study the endometrial cavity in women with infertility as base line investigation. Those in whom abnormalities identified during the study can be taken up for invasive procedure, hysteroscopy. SIS can thus be performed as a preliminary procedure before hysteroscopy.