The need to intensify milk production urgently dictates the need to continue research on the physiology of cattle of any age. It is customary to attach great importance to blood, consisting of uniform elements and plasma, constantly circulating through the vessels. It provides gas exchange, metabolism and the delivery of hormones and bioregulators in their tissues. The success of hemocirculation strongly determines the completeness of the realization of the genetic growth potential and productivity of the animal and is closely related to the activity of aggregation of blood cells. Purpose: to find out the activity of aggregation of the main formed elements of the blood in newborn calves. The work was carried out on 32 newborn calves of black-motley breed, born of healthy cows after 2-3 pregnancies. The calves were examined on 1-2, 3-4, 5-6, 7-8 and 9-10 days of life. In the work, hematological and statistical research methods are applied. For newborns in calves, a tendency towards increased aggregation activity of red blood cells was revealed. This was combined with a low platelet aggregation, which tended to increase. The low aggregation of neutrophils in these calves also gradually increased. In newborn calves of optimal physiological status, there is a tendency to increase the aggregation of the main formed elements of the blood, which is a response to environmental influences.

Background: The microrheological disorders of red blood cells in obesity is often missed by the researchers. This study aimed to report an experimental investigation on laboratory animals with developed obesity and to find out the effect of meldonium on the erythrocytes.Methods: A total of 95 healthy male-rats of Vistar line were taken into the investigation, 29 animals had experienced no impacts and allocated as the control group, while 64 rats which had developed obesity induced by a cardioangionefopathogenic semisynthetic diet into the obesity group. These rats were casually divided into an experimental (34 rats) group and the control group (30 rats). The rats of the experimental group in the next ten days were intragastrically injected with meldonium for 80 mg/kg. The biochemical, hematological and statistical methods of investigation were used in this study.Results: During the formation of obesity and the use of meldonium, the body weight of the rats were gradually decreased to the normal level. On the obese rat's group receiving meldonium, the content of the lipids peroxidation products in erythrocytes progressively decreased.  and reached the level of the healthy control rats group. Moreover, there was a decrease in the number of erythrocytes-discocytes accompanied by an increase in the reversible and irreversible changes. These values were returned to the level of the healthy control rats group at the end of the observation. This pattern was observed in the total number of erythrocytes aggregate and free erythrocytes.Conclusion: The application of meldonium eliminates the existing erythrocytes abnormal microrheological features in the rats with recently developed obesity.

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Estimation of ontogenetic peculiarities of aggregation of regular blood elements and vascular control over it, including calves in the middle of early ontogenesis -in the phase of milk-vegetable nutrition, is of great scientific and practical interest. Clarification of their physiological balance is really significant for receiving the possibility of regulation of hemostasis activity and metabolism intensity in tissues. To estimate aggregative activity of regular blood elements and disaggregating vessels' control over them in calves during the phase of milk vegetable nutrition. We formed a group of calves of black-many-colored breed which were examined 5 times at the age between the 31st and the 90th days of life with the application of biochemical, hematological and statistical methods of Original Research Article

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