Objective We propose a simultaneous extraction method for 12 organs from non-contrast three-dimensional abdominal CT images. Materials and methods The proposed method uses an abdominal cavity standardization process and atlas guided segmentation incorporating parameter estimation with the EM algorithm to deal with the large fluctuations in the feature distribution parameters between subjects. Segmentation is then performed using multiple level sets, which minimize the energy function that considers the hierarchy and exclusiveness between organs as well as uniformity of grey values in organs. To assess the performance of the proposed method, ten non-contrast 3D CT volumes were used. Results The accuracy of the feature distribution parameter estimation was slightly improved using the proposed EM method, resulting in better performance of the segmentation process. Nine organs out of twelve were statistically improved compared with the results without the proposed parameter estimation process. The proposed multiple level sets also boosted the performance of the segmentation by 7.2 points on average compared with the atlas guided

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