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I NTENSIVE DET0XtCATIVE Tf)ER4PY BY XENOHEPaT0CY-gS N.P,Subbota nteneive detoxicative "cellular therapy" requires functioning bank of allooels with preserved organ-specific properties. We showed that donor albo-and xefohepatocytea•,.oryopreeerved by routine technologies, by suprartpid freezing, maintain a high level of viable Celle ‚in suspension, thus providing for an active capture of xenobiotics. application of supralow (-196°C) temperatures guarantees a long-term (10 years or more) maintenanoe of detoxioative properties of oryopreserved cells, making control over the compo-'sition of preserved medium, sterility and biosorbent viability. unnecessary. Experimental studies using. hopstocytfls. of rats, ,dogs, puppies, pigs and humans, and olinioal eaperience on detoxieative therapy by donor ."altocryooeile" make it possible to recommend tspplication of hepatooyte suspension, in an "ertificial liver" device or transport perfusion systems• depending on the level of viable cello in suspensions: low-viability cells may be used only under indirect cell/blood contact (e.g.eatracor= poral dialysis), thus excluding penetration of cell elements into organism during cell lysis. Reliability of maintaining organ-specific properties of.cells in oryobanks provides for a timely treatment by effective natural biosorbents during intensive detoaicative therapy.institute. for Problems of Cryobiology & Cryomedicine, Ukrainian mcad.Sci.,