Background: The effect of antioxidant therapy on sperm DNA fragmentation index (DFI)and achieving natural pregnancy were under debate. Very few studies have showedthe rate of pregnancy rate after the antioxidant therapy due to ethical and technicallimitations.Objective: The aim of this cohort study was to determine the improvement rate ofsperm DFI and natural pregnancy rate after the antioxidant therapy in infertile men.Materials and Methods: 1645 infertile men were subjected for this study from May2015 to December 2017. The Spermogram and sperm DFI were assessed using WorldHealth Organization (WHO) 2010-based protocols and sperm chromatin structure assay(SCSA), respectively, in sperm samples before and after antioxidant therapy.Results: The total sperm DFI improvement rate was 38.9% in the total population.Sperm DFI improvement had close correlation with total motility (r= 0.731, p= 0.001)and progressive motility improvement (r= 0.885, p= 0.001); 16.8% of individuals whocompleted antioxidant therapy for nine months achieved natural pregnancy.Conclusion: The results of the current study suggested that SCSA along withspermogram might be a suitable option for the evaluation of fertility potential. Inaddition, antioxidant therapy may be useful for men with high levels of sperm DFI.However, the rate of pregnancy was still low and other treatment protocols such asassisted reproductive technology may be necessary.

Sarram, M., Iranpour, H., Jabalameli, H. and Kamran, T. (Center of Population Studies and Dept. of Obstetrics and Gynecology, University of Isfahan, Isfahan, Iran). Evaluation of etiologic factors in 405 infertile couples in Isfahan (Iran). Int J Gynaecol Obstet 13: 181–185, 1975. The etiologic factors are reported in 405 infertile couples in Isfahan; data are first to be published on Iranian couples. Wife's age distribution and duration of marriage is reported. The frequency of various etiologic gactors in male and female are presented. It is suggested that in male and female both the severity and the anatomical sites of each factor should be taken into consideration for work‐up and evaluation of infertility. Furthermore it is suggested that, in couples where both husband and wife have pathological findings, the degree of severity of male and femalt factors should be judged. Such couples should be classified separately in statistical studies. Relatively high percentage of secondary infertility was found in our material.

Tne patients with galactorrhea syndrome were treated with two different daily dosages (5 mg and 7.5 mg) of Bromergocryptine. The 5 mg daily dosage often did not produce the desired hormonal and clinical response. Five patients were treated with this regimen for 38 to 90 days, with treatment extending over more than one menstrual cycle. However, the 7.5 mg daily dosage resulted in complete cessation of galactorrhea in all patients, restoration of menstrual cycles in five patients, and pregnancies in four patients. Disappearance of lactation proved to be a very good indicator of the general responsiveness of patients. Nausea, vomiting, and occasional dizziness were side effects of the drug. The case histories and hormonal findings of four typical patients are reported.