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Bortezomib (BTZ) is a first in class, potent reversible inhibitor of proteasome used in the treatment of multiple myeloma, the second most common hematological cancer. Stress degradation studies were performed...

An efficient synthesis of 3,4-dihydropyrimidinones (DHPMs) using bismuth (III) nitrate as a catalyst for the first time from an aldehyde, β-keto ester and urea in acetonitrile is described. Compared to the classical Biginelli reaction conditions, this new method consistently has the advantage of excellent yields (80-93%) and short reaction time (1.5-2.5 hours) at room temperature.