In this Letter we report the discovery of TeV gamma-ray emission from a supernova remnant made with the CANGAROO 3.8 m telescope. TeV gamma rays were detected at the sky position and extension coincident with the northeast rim of shell-type supernova remnant (SNR) SN 1006 (Type Ia). SN 1006 has been a most likely candidate for an extended TeV gamma-ray source, since the clear synchrotron X-ray emission from the rims was recently observed by ASCA (Koyama et al.), which is strong evidence for the existence of very high energy (up to hundreds of TeV) electrons in the SNR. The observed TeV gamma-ray flux was (2.4 ‫ע‬ 0.0.7 [systematic]) # 10 3.0 ‫ע‬ 0.9 (4.6 ‫ע‬ 0.6 ‫ע‬ 1.4) # 10 1.7 ‫ע‬ 0.5 from the 1996 and 1997 observations, respectively. Also, we set an upper limit on the TeV gamma-ray emission from the southwest rim, which is estimated to be cm Ϫ2 s Ϫ1 (≥ TeV, 95% confidence level) Ϫ12

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We have observed the Vela pulsar region at TeV energies using the 3.8 m imaging Cherenkov telescope near Woomera, South Australia between January 1993 and March 1995. Evidence of an unpulsed gamma-ray signal has been detected at the 5.8 sigma level. The detected gamma-ray flux is (2.9 +/- 0.5 +/- 0.4) x 10^-12 photons cm^-2 sec^-1 above 2.5 +/- 1.0 TeV and the signal is consistent with steady emission over the two years. The gamma-ray emission region is offset from the Vela pulsar position to the southeast by about 0.13 deg. No pulsed emission modulated with the pulsar period has been detected and the 95 % confidence flux upper limit to the pulsed emission from the pulsar is (3.7 +/- 0.7) x 10^-13 photons cm^-2 sec^-1 above 2.5 +/- 1.0 TeV.Comment: 18 pages, 3 figures, LaTeX with AASTeX, accepted for publication in ApJ Letter

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1 Extracts of bitter melon, soybean, dokudami and welsh onion by 40% methanol increased the accumulation of rhodamine-123 by Caco-2 cells, suggesting that these extracts inhibited Pglycoprotein (P-gp). 2 The extract of bitter melon was separated in a tC18 cartridge column and the eluate from 80% acetonitrile most markedly increased the [ 3 H]-daunomycin accumulation by Caco-2 cells. 3 The inhibitory compounds in the bitter melon fraction were isolated by HPLC with Pegasil C4 and Pegasil ODS columns. The HPLC fraction having the highest activity was analyzed by 1 H-NMR and FAB-MS, and the active compound was identified as 1-monopalmitin. 4 The inhibitory activities of 1-monopalmitin and its related compounds suggested that the inhibition of P-gp activity was not dependent on the degree of unsaturation of fatty acid in the monoglyceride, but on the chain length. It was also suggested that the monoglyceride structure played an important role in the inhibition of P-gp activity. 5 Monoglycerides could therefore alter the pharmacokinetics of drugs by inhibiting the P-gpmediated efflux.