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Electronic poster abstractsfrom the program we use to calculate the combined first trimester screening: CRL, IP AUt, history of diabetes and PAPPA. Of the 60 pre-eclampsias only achieved the required data in 27. Results: Of the 1601 patients studied, 1574 did not develop pre-eclampsia and 27 did. Of these, 2 of them did earlier and 25 did over 34 gestational weeks. Of the 1574 controls 130 obtained a high risk of developing the disease when the cut-off is equal or greater than a probability of 1/70 . Nevertheless, the 27 cases 10 obtained a high risk, of them, 8 developed pre-eclampsia after 34 gestational weeks and 2 did it before. Consequently, Clinic calculator would have detected 32% of late cases and 100% of early when cut-off 1/70. If we would have establish a preventive treatment in all high risk patients we would have treated 140 patients to avoid 10 cases. Conclusions: Even in a population like ours with a low prevalence of pre-eclampsia, mainly early variety, it seems like Clinic screening is an acceptable method of disease detection. P14.15Progesterone effect on fetal Doppler velocimetry in in pregnant women with IUGR and preterm labour S. Borna Tehran University of Medical Sciences, Tehran, Islamic Republic of IranObjectives: The purpose of this study was to determine whether supplementation of vaginal progesterone affects on fetal Doppler velocimetry. Methods: Thirty patients with intrauterine growth retardation fetuses and thirty pregnant women with threatened preterm labour fetuses were enrolled in the study. Fetal Doppler velocimetry was investigated before, 24 hours and two weeks after administration of vaginal progesterone. Results: All fetuses demonstrated a significant decrease in PI and RI of fetal middle cerebral artery in both preterm and IUGR groups in three times. (P < 0.001). The reduction in PI, S/D and RI of umbilical artery after 24 hours was not significant, whereas after two weeks of treatment the reduction in PI was significant (P 0.004). Conclusions:The use of vaginal progesterone suppository led to a reduction middle cerebral artery PI and umbilical artery PI. It can improve fetoplacental perfusion in pregnancies complicated by IUGR and preterm labour. P14.16Could high volume of physical activities in early pregnancy could delay or impair deep placentation? Objectives: Physical activity (PA) has been hypothesized to reduce the risk of Pre-eclampsia (PE) but with inconsistent results: one of the largest studies found an increased risk of severe PE with high-level of PA and a recent study observed that PA was inversely correlated with first-trimester maternal serum PlGF, a marker of deep placentation. We aimed to evaluate such association in women with high volume of PA. Methods: Women participating in a first-trimester (11-13 weeks) prospective study were asked about their PA. Women who reported more than 3 hours of sustained PA per week were included. Several biomarkers of deep placentation were evaluated, including: mean UtA pulsatility index (PI); PAPP-A MoM; placental volume;...

Electronic poster abstractsInter-observer agreement was assessed using the Kappa statistics with bootstrapped 95% confidence intervals (CI). Results: The kappa for inter-observer agreement in presence of uterine artery Doppler notching was 0.82 [95% CI: 0.72 to 0.92], which was interpreted based on the standards of Landis & Koch to reflect excellent agreement. Conclusions: Despite the subjective nature of uterine artery Doppler notching assessment, high inter-observer variability supports its use in clinical practice in a cohort of high-risk women P14.22 Utero-placental vascularization by 3D power Doppler during first trimester: predictive value for placental vascular disease. Objectives:The aim was to evaluate the predictive value of 3D power Doppler (3DPD) quantification of placental and myometrium vascularisation at the end of the first trimester for the prediction of secondary placental vascular diseases (PVD), pre-eclampsia and IUGR. Methods: Acquisition of utero-placental volume was performed prospectively in 127 patients (67 low risk and 60 high risk women), between 11 and 14 weeks, using a standardized abdominal 3DPD procedure. Placental and myometrial vascularization were quantified separately using the VOCAL. Values obtained from patients with PVD were compared with those with favourable outcome. Results: In low risk population, PVD occurred in 6 cases (1 pre-eclampsia, 1 gestational hypertension associated to IUGR and 4 isolated IUGR). All placental 3DPD indices (VI, FI and VFI) significantly decreased in patients who developed PVD (p < 0.01) {mean VI: 1,73 vs 6,9; VFI: 0,59 vs 2,81 and FI 33,41 vs 41,49} whereas in myometrium, only VI and VFI were reduced (p < 0.05) {mean VI: 12,97 vs 20,97; VFI: 5,6 vs 10,27}. Among high risk women, PVD occurred in 15 cases (13 IUGR of which 3 with associated pre-eclampsia, 2 gestational hypertension). Any significant differences where found for placental indices or volumes. But regarding myometrium all 3D PD indices (VI, FI and VFI) significantly decreased in patients who developed PVD (p < 0.01) {mean VI: 11,09 vs 21,71; VFI: 4,39 vs 10,92 and FI 44,58 vs 49,15}. Conclusions: In PVD, utero-placental vascularization is impaired very soon in pregnancy. This technique could be a way to detect patients at high risk of PVD in general as well as in high risk population and to select patients needing preventive treatment and increased medical monitoring.

Short oral presentation abstracts for Down-syndrome. We prospectively measured and compared prenasal soft tissue thickness (PT) and nasal bone length (NBL) in second trimester euploid and trisomy-21 fetuses. Methods: Using 2D abdominal ultrasound the measurement of PT and NBL was taken in mid-sagittal plane of the fetal head identifying diencephalon, tip of the nose, lips, maxilla, mandible, nasal bone in weeks 16-23 in the second trimester. The PT is the shortest distance from the bottom edge of the os frontale to the outer surface of the overlying skin. The nasal bone was measured from this view. The insonation angle was 90 • (perpendicular) to the nasal bone. NBL/PT ratios of euploid fetuses between 16-23 weeks were analyzed and validated by Shapiro-Wilke test. We used software (SigmaStat 12 & SigmaPlot 12) to create graphs, the regression line and the percentiles curves (5 th-25 th-75 th-95 th) have been calculated from the normal values. We used the normal graphs to visualize and compare trisomy 21 cases to euploids (P < 0.0001). Results: Analyzes of 810 euploid and 19 fetuses with trisomy 21 measured between the 16-23 gestational weeks were done. In euploid fetuses the mean PT and NBL increased steadily between 16 and 33 weeks' gestation. The difference in the median PT values between the two groups was greater than would be expected by chance. There was a statistically significant difference (P = <0.001) Mann-Whitney Rank Sum Test. All of the 19 fetuses with trisomy 21 the NBL/PT values were lower than 5 th percentile curve of the euploid group. Conclusions: CIn fetuses with trisomy 21 the NBL/PT ratio was significantly lower compared to euploid ones. The NBL/PT ratio was found to be very sensitive and specific marker for trisomy 2.