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BACKGROUND Food allergies negatively affect quality of life and can be a significant medical burden. Allergic reactions to cashew nuts can often be severe and are rarely outgrown. The Ana o 3 protein is an immuno-dominant cashew allergen. Ana o 3 is a small 13kDa protein composed of 2 subunits held together by disulfide bonds that can be disrupted by treatment with reducing agents. The stability and solubility properties of Ana o 3 make it an excellent target for detection methods and tools.