In the clinical efficacy test of four skin-improvement parameters, adenosine-loaded dissolving microneedle patches showed the same or better effect than the adenosine cream, although the weekly adenosine dose was 140 times lower. The dissolving microneedle patches caused no adverse reactions. These adenosine-loaded dissolving microneedle patches are expected to be safe, effective, and novel cosmetics for skin improvement.

Developed the new technique to modify cotton fiber by esterification with citric acid, the reaction was carried out in the tight flask and applied argon as anti-burning reagent. The optimum condition was 170oC, 5h and 3g of citric acid per 2g of cotton fiber, which result was up to 0.88 mol citric acid grafted on 1 mol glucose. The modified cotton fiber thereafter was applied to purify epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) from green tea polyphenol by column chromatography with the suitable mobile phase.