Evoked potentials (EPs) have been widely used to quantify neurological system properties. Changes in EP latency may indicate impending neurological dysfunctions. This paper provides a review and a performance comparison of three classes of latency change estimation algorithms: correlation based, adaptive least mean square (LMS) based, and p-norm based algorithms. Data analysis based on computer simulated data and data from impact acceleration and hypoxia experiments were conducted. This concluded that correlation-based algorithms should only be used when the expected latency change is fixed and the noises are not correlated. While all adaptive LMS type algorithms were capable of tracking and estimating latency changes (fixed or variable) under Gaussian noise conditions, the direct LMS-based algorithm reduced the estimation error power given by traditional filter type LMS algorithms as much as 93%. When periodic interference was present, the frequency selective LMS algorithms outperformed other LMS-based algorithms and reduced of the estimation error power by 89%. Alpha-stable noise processes are better approximations of noises found in various EP analysis applications and adaptive p-norm based algorithms are found to be very robust under such noise conditions, eliminate erroneous abrupt latency changes other algorithms would have produced.