No abstract

A new class of benzazolyl azolyl sulfamoyl acetamides was prepared from azolyl sulfamoyl acetates and benzazolyl amines in the presence of KOtBu in tetrahydrofuran. Compounds with benzothiazole‐thiazole, benzimidazole‐thiazole, benzothiazole‐imidazole, and benzimidazole‐imidazole moieties exhibited excellent antibacterial activity against Bacillus subtilis.

A variety of thiophenylazolyl pyrrolylsulfamoyl acetamides were prepared by the reaction of azolylsulfamoyl acetate with pyrrolylamine in the presence of sodium methoxide in methanol under ultrasonication. Chloro, nitro and dinitro substituted thiophenylthiazolyl pyrrolylsulfamoyl acetamides (9d, 9e, 9f) and dinitro substituted thiophenylimidazolyl pyrrolylsulfamoyl acetamide (10f) exhibited potential antibacterial activity against B. subtilis. The compound 9f also displayed prominent antibacterial activity against S. aureus. The compounds 9f, chloro and nitro substituted thiophenylimidazolyl pyrrolylsulfamoyl acetamide (10d, 10e) and 10f exhibited prominent antifungal activity against A.niger.

Systematic analysis of pre-donation deferral reasons guides the transfusion society to undertake necessary steps towards the retention and re-entry of the temporary deferrals. Aim of our centre’s study is to find out the causes for deferral in detail and to reduce the pre-donation deferrals to an extent that give appreciable results. One year donor details from January 2019 to December 2019, collected from the properly maintained registers, grouped and studied with respect to age, gender and reason for deferral.Deferred donors were 184 out of 2083 registered volunteersThe number of males deferred were higher (139/184; 75.54%) than females (45/184; 24.46%), but the deferral rate was higher in females (45/109; 41.28%). Temporary deferral (84.23%) accounted more than 4/5 of the total deferrals.As our study, most of the studies in literature indicate higher percentage of donor deferrals due to temporary causes. Suitable temporary deferrals can be brought back into the donor pool after completion of the treatment by giving proper counselling about the reason and period of deferral.