Summary A unique chaotic spreading sequence‐based MC‐CDMA (multi‐carrier code division multiple accesses) is studied in this article. By employing this spreading sequence, interference effect that is inherent in a multi‐user environment can be lessened by deciding on the spreading series with suitable cross‐correlation properties. The simulation study exhibits that chaotic sequence‐based MC‐CDMA acts well in a multiuser setting, resulting in better attainable error rates. Moreover, results confirm that chaotic sequence‐based MC‐CDMA beats the Walsh Hadamard code spreading‐based MC CDMA system. The inception of MIMO (Multiple Input Multiple Output) scheme leads to the augment in the number of antennas that are present in the transmitting in addition to receiving side. This induces an enhancement in the throughput and the robustness of the communication system. Further, the simulation outcomes exhibit that the suggested technique is far beneficial in the context of combating MAI (multiple access interference) and aids to achieve performance amelioration concerning the utility of approximately 9%.