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The fusion cross sections for the reactions of all the projectile-target combinations found in the cold valleys of 286 112 have been studied using scattering potential as the sum of Coulomb and proximity potential, so as to predict the most probable projectile-target combinations in heavy ion fusion reactions for the synthesis of super heavy nucleus 286 112. While considering the nature of potential pockets and half lives of the colliding nuclei, the systems 82 Ge + 204 Hg, 80 Ge + 206 Hg and 78 Zn + 208 Pb found in the deep cold valley region and the systems 48 Ca+ 238 U, 38 S+ 248 Cm and 44 Ar+ 242 Pu in the cold valleys are predicted to be the better optimal projectile-target combinations for the synthesis of super heavy nucleus 286 112.