No abstract

In present study, a novel random copolyester i.e. poly(3-oxy-5-methylphenyl-4-oxynaphthal-1- yl)isophthalate (PONI) was synthesized through solution polycondensation methodology involving orcinol, 1,4-naphthalene diol and isophthaloyl chloride and its solubility in common solvents along with viscosity measurements were performed. The structure of the repeat units in the polyester chain were ascertained based on the spectral characterization of UV-visible, FTIR, 1H & 13C NMR techniques. Thermal analysis of the copolyester were performed by TGA and DSC studies. The activation energy for thermal decomposition of polyester was estimated by well-known kinetic methods. The surface morphology and crystalline nature of the polymer were explored by employing SEM and WAXD methods. The antimicrobial efficacy of copolyester was assessed through well-diffusion method using a Gram-positive and a Gram-negative bacteria. The in vitro cytotoxicity of the polyester prepared was verified against HeLa cell line using MTT assay.

In this investigation, a new wholly aromatic random copolyester containing 4,4'-dihydroxybiphenyl, 3,5dihydroxytoluene and Isophthaloyl chloride was synthesized using the solution polycondensation methodology in the mole ratio 2:1:3 and its solubility along with inherent viscosity were determined. The chemical structure of the copolyester was established by traditional spectroscopic techniques. The physical parameters of the polyester were studied employing WAXD studies and the thermal stability along with phase transitions were investigated employing TGA and DSC data. The morphological features in the polyester were probed using Scanning Electron Microscopy. The anticancer activity of copolyester was verified using HeLa (Cervical carcinoma) cell line employing MTT assay.