Glycine max. L. Merril. is one of Indonesia’s strategic commodities, whose productivity can be increased by using moringa leaf extract (Simplicia extract) and cow manure. This research aims to determine the effect of the dose of Simplicia extract and cow manure on the growth and yield of soya beans. The research was carried out from October to December 2020. The soil type was regosol in Jagalan Village, Karangnongko District, Klaten Regency, Central Java. The research design used the factorial method with a completely randomized design (CRD) which consisted of 2 factors; the first factor was dose variations of Simplicia extract (M) were 0, 10, 20, 30, 40, and 50 ml./L (M0, M1, M2, M3, M4, and M5), the second factor is cow manure (C) which is 30 and 60 g/polybag (P1 and P2). The results showed that the combination treatment of M5P2 at a dose of 50 ml/L of Simplicia extract and 60g/polybag of cow manure had the highest growth and yield compared to other treatments. This research provides information on appropriate doses of Simplicia extract and cow manure on soya bean yield and growth.