Hemorrhagic fever with renal syndrome (HFRS) is a public health problem in Vladivostok city, Russia. From 1997 to 2019, a study of hantaviruses in Norway rats (Rattus norvegicus), a natural reservoir of Seoul virus (SEOV), and in HFRS patients was conducted. We demonstrated the presence of SEOV in the local population of Norway rats and detected SEOV in 10, Amur virus (AMRV) in 4 and Hantaan virus (HTNV) in 1 out of 15 HFRS patients. Genetic analysis based on partial S, M and L segment sequences revealed that the Russian SEOV strains were related most closely to strains from Cambodia and Vietnam. We postulate that the SEOV strains found in the port city of Vladivostok have been spread from South-East Asia as a result of distribution of rats during standard shipping trade activities. Moreover, we suggest that city residents may have acquired AMRV and HTNV infection during visits to rural areas.

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There are presented data on group cases of hemorrhagic fever with renal syndrome (HFRS) in the foci of distribution of mouselike rodents - the carriers of pathogenic genotypes of hantaviruses. A relationship between HFRS incidence and the period of acute manifestations of infection in rodents has been revealed. According to detection by RT-PCR specific RNA on substrates of environment there were designated the possible factors of transmission of the agent.

Having based on well-known limiting cases, we constructed the approximate solutions of equilibrium equations for nematic liquid crystals for the radial (R) and hyperbolic (€I) point defects in a capillary with normal boundary conditions. On the contrary to the point of view accepted before we have to claim that because of equivalence of both directions of "escaping" along the capillary axis the bound R-and Hdefects occurred instead of non-singular disclination. The comparative analysis of elastic fields of free and bound R-and Hdefects has been given. It has been shown that the boundaries do not influence on topology of the elastic fields and far from the singularities the structure coincides with the structure of a non-singular disclination. It has been obtained that the difference between the energies of the R-and Hdefects in the bound state is half as much as the correspondent value for the free defects.