Introduction. Androgenetic alopecia (AGA) is the most common type of alopecia, characterized by diffuse progressive thinning of the hair in the fronto-parietal area in patients with a genetic predisposition. Topical minoxidil remains the primary pharmacological treatment for AGA both in men and women. The efficacy in hair regrowth is reported to be between 40 and 50%.Aim. To evaluate prognostic factors of minoxidil response in AGA patients.Matherials and methods. The prospective open study was carried out. Thirty participants with AGA were enrolled and completed the study (twenty one women I–II Ludwig stage and nine men I–III Hamilton – Norwood stage). Primary outcomes consisted of measuring of hair density, telogen hair rate, the percentage of vellus hairs and hair diameter at baseline and repeated at 4 months. The SULT1A1 enzyme activity and the concentration of ATP in plucked hairs were measured at baseline. Patients were treated with 5% topical minoxidil applying daily for 4 months. In order to investigate prognostic factors in groups of responders and non-responders to minoxidil treatment these measured morphometric and biochemical characteristics were assessed.Results. After 4 months of treatment 77% of patients demonstrated hair regrowth and improvement of hair density, hair diameter and decrease of vellus hairs level. The SULT1A1 enzyme activity (p = 0.0008), the concentration of ATP (p = 0.004) in plucked hairs and baseline total hair density (p = 0.01) was significantly lower in group of non-responders compared to group of responders. The study demonstrated strong positive correlation between SULT1A1 enzyme activity and increase of total hair density (r = 0.7, р = 0.00002); moderate positive correlation was founded between concentration of ATP and increase of total hair density (r = 0.6, р = 0.0004).Conclusion. The negative prognostic factors for minoxidil treatment of AGA include SULT1A1 enzyme activity, concentration of ATP in plucked hairs and low total hair density at baseline.

андрогенетическая алопеция -генетически детерминированный хронический процесс миниатюризации фолликулов теменной зоны под действием андрогенов. В качестве основного диагностического метода, выявляющего морфо-метрические изменения волос, характерные для аГа, в рутинной трихологической практике чаще всего применяется фототрихограмма. Топические формы препарата миноксидил на сегодняшний день остаются основным фармакологи-ческим вариантом лечения андрогенетической алопеции. исследования продемонстрировали высокую эффективность препарата в отношении увеличения толщины волос в лобно-теменной зоне. однако в большинстве из этих работ учтены лишь некоторые из диагностически значимых критериев фототрихограмм. В проведенном исследовании была про-анализирована динамика показателей фототрихограмм на фоне терапии 5% пеной миноксидила, а также их связь с качеством жизни пациентов. androgenetic alopecia (aga) is the genetically determined androgen-induced chronic miniaturization of follicles in the parietal region. The phototrichogram technique is the main diagnostic tool identifying morphometric changes in hair typical of aga that is used most commonly in trichological practice. Today, topical forms of minoxidil remain the primary pharmacological treatment for androgenetic alopecia. research results have shown high efficacy of this pharmaceutical in increasing hair thickness at the frontoparietal region. however, in most of these studies, only some of the diagnostically relevant criteria of phototrichogram were taken into account. The study analyzed the dynamics of phototrichogram indexes during therapy with 5% minoxidil foam, as well as their relationship with the quality of life of patients.

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