No abstract

No abstract

No abstract

No abstract

Synthesis and Antiarrhythmic Activity of 4-Aryl-5-nitro-6-phenyl-3,4-dihydro-(1H)-pyrimidin-2-ones.-A variety of novel title nitro-substituted dihydropyrimidinones (IV) is prepared by condensation of urea (I) with aromatic aldehydes (II) followed by cyclocondensation with αnitroacetophenone (III). The novel derivatives possess promising antiarrhythmic activity accompanied with low toxicity. Especially the p-hydroxyphenyl (IVb) and m-fluorophenyl derivatives (IVd) show enhanced activity. -(SEDOVA, V. F.; VOEVODA, T. V.; TOLSTIKOVA, T. G.; SHKURKO, O. P.; Khim.-Farm. Zh. 36 (2002) 6, 4-7; Novosibirskii inst. org. khim. im. Vorozhtsova Sib. otd. Ross. akad. nauk, Novosibirsk 630090, Russia; RU)