The aim of the research. To study the dynamics of mortality in the Krasnoyarsk region from the blood circulation system diseases. Materials and methods. It was used the information of GBUZ Medical Information-Analytical Center of Ministry of Health of the Krasnoyarsk Region and Territorial Authority of the Federal State Statistics Service of the Krasnoyarsk Region about the quantity of dead and the distribution by sex, age and cause of death in the period 2005-2012 years (Form C51), and the quantity of population with distribution by sex and age for the same years on Krasnoyarsk Region and the Russian Federation (form 2pH). Results. The general tendency of reducing mortality from this pathology in the Krasnoyarsk Region in the given period of time is not significantly different from similar indicators in the country. At the same time, in the Krasnoyarsk Region were detected quicker mortality reduce from cerebrovascular pathology, and conversely a slow reduce of this indicator from coronary heart disease. Conclusion. The data obtained can be used in the planning of preventive measures in patients with diseases of the cardiovascular system in the Krasnoyarsk Region.