This paper presents investigation of nickel additions on the low-alloy Cr-Mo cast steel which was normalized at temperature of 920 °C. In this experiment, approximately 0.3, 0.5, and 1.0 wt% Ni was added into the Fe-1.0Mn-0.8Cr-0.4Mo cast steel. The microstructure of low-alloy Cr-Mo cast steel was observed by optical microscope and scanning electron microscope, and the phase compositions were identified by EDX analysis. Tensile, hardness, and Charpy impact tests were conducted to investigate correlation between nickel additions to microstructure characteristics and mechanical properties. The results show that increasing nickel from 0.3 to 1.0 wt% on the alloys has improved the strength without sacrificing the impact toughness. Ni addition into low alloy steel increased the austenite stability due to the grain refinement. The strength was found increase linearly with Ni addition which may caused mainly by solid solution strengthening due to Ni dissolved into the ferrite matrix.