No abstract

No abstract

Griseofulvic acid (I; R = H) is converted by phosphoryl chloride in the presence of water and lithium chloride into a mixture of the 2'-and the 4'-chloride (11; R = H, R' = C1 and 111; R = H, R' = C1, respectively); 3'-substituted griseofulvic acids with the same reagents give predominantly 4'-chlorides. However, 4'-amines (111; R' = NH,) and some 4'-ethers give 2'-chlorides under these conditions, whereas S'-amines and ethers give predominantly 4'-chlorides. 2'-and 4'-Chlorides react under alkaline conditions with thiols to give 2'-and 4'-S-alkyl compounds, and with phenol and lower alcohols to give 2'-and 4'-ethers. Chlorides of both series react with ammonia and other bases to give the corresponding amines.

No abstract

No abstract