On May 21, 2019 at 03:02:29 UTC Advanced LIGO and Advanced Virgo observed a short duration gravitational-wave signal, GW190521, with a three-detector network signal-to-noise ratio of 14.7, and an estimated false-alarm rate of 1 in 4900 yr using a search sensitive to generic transients. If GW190521 is from a quasicircular binary inspiral, then the detected signal is consistent with the merger of two black holes with masses of 85 þ21 −14 M ⊙ and 66 þ17 −18 M ⊙ (90% credible intervals). We infer that the primary black hole mass lies within the gap produced by (pulsational) pair-instability supernova processes, with only a 0.32% probability of being below 65 M ⊙. We calculate the mass of the remnant to be 142 þ28 −16 M ⊙ , which can be considered an intermediate mass black hole (IMBH). The luminosity distance of the source is 5.3 þ2.4 −2.6 Gpc, corresponding to a redshift of 0.82 þ0.28 −0.34. The inferred rate of mergers similar to GW190521 is 0.13 þ0.30 −0.11 Gpc −3 yr −1 .

GW170817 is the very first observation of gravitational waves originating from the coalescence of two compact objects in the mass range of neutron stars, accompanied by electromagnetic counterparts, and offers an opportunity to directly probe the internal structure of neutron stars. We perform Bayesian model selection on a wide range of theoretical predictions for the neutron star equation of state. For the binary neutron star hypothesis, we find that we cannot rule out the majority of theoretical models considered. In addition, the gravitational-wave data alone does not rule out the possibility that one or both objects were low-mass black holes. We discuss the possible outcomes in the case of a binary neutron star merger, finding that all scenarios from prompt collapse to long-lived or even stable remnants are possible. For long-lived remnants, we place an upper limit of 1.9 kHz on the rotation rate. If a black hole was formed any time after merger and the coalescing stars were slowly rotating, then the maximum baryonic mass of non-rotating neutron stars is at most , and three equations of state considered here can be ruled out. We obtain a tighter limit of for the case that the merger results in a hypermassive neutron star.

The design and fabrication of a dielectrophoretic 'lab-on-a-chip' device for bioparticle processing and counting is presented. The device consists of a multi-layer travelling wave dielectrophoretic electrode array for manipulating particles and/or fluids, microchannels for delivering samples and optical fibres for counting particles and/or measuring their velocities. Single particles were detected optically using either light scattering or fluorescence emission. The technology described in this study is potentially applicable to a range of particulate diagnostic systems.

The impact of commensal bacteria on the host arises from complex microbial-diet-host interactions. Mapping metabolic interactions in gut microbial communities is therefore key to understand how the microbiome influences the host. Here we use an interdisciplinary approach including isotope-resolved metabolomics to show that in Drosophila melanogaster, Acetobacter pomorum (Ap) and Lactobacillus plantarum (Lp) establish a syntrophic relationship to overcome detrimental host diets and identify Ap as the bacterium altering the host's feeding decisions. Specifically, we show that Lp generates lactate which is used by Ap to produce and provide amino acids that are essential to Lp allowing it to grow in imbalanced diets. Lactate is also necessary and sufficient for Ap to alter the fly's protein appetite. Our data show that gut bacterial communities use metabolic interactions to become resilient to detrimental host diets and to ensure the constant flow of metabolites used by effector bacteria to alter host behaviour.Drosophila, feeding behaviour, microbiome, commensal bacteria, nutrition, bacterial communities, essential amino acids, syntrophy, metabolic crossfeeding, Acetobacteracaea, Lactobacilli Correspondence: carlos.ribeiro@neuro.fchampalimaud.org