A simple, efficient and green chemical ultrasound assisted thio-Michael addition reaction between thiols and (Z)-azlactones aiming non-natural amino acid derivatives using chiral Zn[(l)-Pro]2as a heterogeneous catalyst is herein described.
Herein we present a new, highly efficient (60‐ 98 %), low cost and easy procedure for the addition of thiols to N‐Boc imines catalyzed by [Zn(L‐Pro)2] aiming the construction of some different N,S‐acetals by using a low catalytic loading (1 % mol) in short reactions time and under mild conditions.
An efficient method has been developed for the preparation of α-aminophosphonates by using zinc di(L-prolinate) as a catalyst under mild reaction conditions. The method has the advantages of high yields, short reaction times, and easy workup conditions.
The synthesis of isatin-derived N,S-acetals using cobalt as a recyclable heterogeneous catalyst in batch and continuous flow is reported for the first time. The present protocol produced high yields, which can be observed from the reaction between ketimines and thiols. Such reactions can also be applied to a gram-scale. In addition, the catalyst is recyclable, economically-viable, and nontoxic as well as easy to prepare. The remarkable features of this new methodology are high conversion and cleaner reaction profiles.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.