Diabetes mellitus is a multiple etiology syndrome resulting from partial or total lack of insulin. The long-term consequences may be serious complications, including vision problems, limb amputations, with possible progression to renal failure and other diseases. The study focus was to evaluate the pharmacotherapeutical profile of type 2 diabetic patients from Duque de Caxias district in the city of São Luiz Gonzaga/RS. A cross-section observational prospective study was conducted. The variables studied were: gender, age, time of diagnosis, knowledge about the clinical symptoms, dosage blood glucose monitoring and used medications. We interviewed twenty-five patients of whom 56% were male (14/25). The mean age of respondents was 60.2 years old and the diagnosis time in most patients is less than ten years 84%. The most common symptoms were fatigue and dizziness in 20% patients (5/25), somnolence and feet numbness were cited by 16% patients (4/25). Regarding blood glucose levels presented fasting, 32% patients (8/25) showed 100-140 mg/dL, 36% patients (9/25) 140-200 mg/dL, 24% (6/25) 200-400 mg/dL and 8% (2/25) above 400 mg/dL. The medications most commonly used were metformin 36% (9/25), followed by glibenclamide 24% (6/25), although 40% (10/25) said to be in use of both drugs. Diabetes Mellitus presented himself as a disease little known to the own patients, thus education programs and guideline for diabetic patients are essential.