Estimation of prediction accuracy is important when our aim is prediction. The training error is an easy estimate of prediction error, but it has a downward bias. On the other hand, K-fold cross-validation has an upward bias. The upward bias may be negligible in leave-one-out crossvalidation, but it sometimes cannot be neglected in 5-fold or 10-fold cross-validation, which are favored from a computational standpoint. Since the training error has a downward bias and K-fold cross-validation has an upward bias, there will be an appropriate estimate in a family that connects the two estimates. In this paper, we investigate two families that connect the training error and K-fold crossvalidation.

Background: Proteomic data obtained from mass spectrometry have attracted great interest for the detection of early-stage cancer. However, as mass spectrometry data are high-dimensional, identification of biomarkers is a key problem.

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