Nanoparticles are small and have a large surface-to-volume ratio, which gives them phenomenal, unique features. It is an emerging, multidisciplinary field that frequently employs new techniques and tools from diverse disciplines, including biology, engineering, chemistry, and medicine. Nanotechnology entities help to improve the solubility, absorbability, bioavailability, and half-life of conventional natural products. Nano-applications are used in poultry and animal production systems using available tools and techniques without affecting animal health and welfare. Nanotechnology is a smart technology in the field of biomedical engineering used for the diagnosis and treatment of different poultry diseases. This technology provides better solutions for various applications and poultry production that can help in reducing costs and improving the final product quality. Even though nanotechnology is one of the main novelties which have already been applied in poultry and other different areas, it is still in the initial stages of its development and it hampers the environment, animal, and people’s health. Therefore, wide hazard assessments should be conducted to ensure the safety of the nanoproducts before making them immediate implementation for poultry/animal/ or human use.