Introduction:Lymphocytes are cells within the immune system that originate in the bone marrow (B lymphocytes) or thymus (T lymphocytes). It was thought that lymphocytes are not implied in the pathogenesis of vitiligo, but now we can confirm that T cell response rather than B cell humoral immune response is essential in the pathogenesis of vitiligo. Aim of work:To further understand the role of lymphocytes in vitiligo.Methods: Data were collected from the most recent and relevant manuscripts to clarify the role of lymphocytes in vitiligo with the most updated publications.Results: Melanocyte-specific, cytotoxic CD8+ T cells abundantly infiltrate active vitiligo lesions leading to the destruction of melanocytes. Specific cytotoxic T cells destroy targeted melanocytes by the release of Perforin, Granzyme, TNF-α, IFN-γ, and the Fas apoptotic proteins.