This review summarizes the synthesis, reactions, and biological activities of tetrazolo[1,5-a]quinoline derivatives. These derivatives were synthesized by several methods such as i) from the reaction of 2-chloroquinoline with sodium azide ii) from diazotization 2-hydrazinylquinoline derivatives, and iii) from intramolecular cyclocondensation of 2-azidoarylidenes. Also, the chemical reactions and pharmacological activities of some tetrazoloquinolines such as tetrazolo[1,5-a]quinoline-4-carbaldehyde, 5-chlorotetrazolo[ 1,5-a]quinoline, 4-(chloromethyl)tetrazolo[1,5-a]quinoline, tetrazolo[1,5- a]quinoline-4-carboxylic acid, and 5-azidotetrazolo[1,5-a]quinoline were discussed.

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: This review deals with the synthetic methods and pharmacological properties of [1,2,3]triazoloquinoline derivatives. There are ten isomers of fused [1,2,3]triazoloquinoline according to the junction between triazole and quinoline. The synthetic methods are subdivided into groups according to type of isomers. Pharmacological activity of [1,2,3]triazoloquinolinewas also reported.